Ppp1r14d MGI Mouse Gene Detail - MGI:1919362 - protein phosphatase 1, regulatory inhibitor subunit 14D

Symbol

Ppp1r14d
Name

protein phosphatase 1, regulatory inhibitor subunit 14D
Synonyms

2010107K19Rik

Feature Type

protein coding gene
IDs

MGI:1919362
NCBI Gene: 72112
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:119048600-119060387 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.97 cM, cytoband E5
Mapping Data

2 experiments

SNPs within 2kb

428 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919362	protein coding gene	Chr2:119048600-119060557 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026337	protein coding gene	Chr2:121955374-121967033 (-)
A/J	MGP_AJ_G0026298	protein coding gene	Chr2:116994557-117006102 (-)
AKR/J	MGP_AKRJ_G0026277	protein coding gene	Chr2:120271985-120283670 (-)
BALB/cJ	MGP_BALBcJ_G0026311	protein coding gene	Chr2:117257976-117271063 (-)
C3H/HeJ	MGP_C3HHeJ_G0026057	protein coding gene	Chr2:120737830-120750753 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026758	protein coding gene	Chr2:125969757-125982148 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024138	protein coding gene	Chr2:112046729-112059678 (-)
CAST/EiJ	MGP_CASTEiJ_G0025519	protein coding gene	Chr2:121046252-121059551 (-)
CBA/J	MGP_CBAJ_G0026033	protein coding gene	Chr2:130401536-130417922 (-)
DBA/2J	MGP_DBA2J_G0026172	protein coding gene	Chr2:116419929-116431703 (-)
FVB/NJ	MGP_FVBNJ_G0026134	protein coding gene	Chr2:115238717-115251411 (-)
LP/J	MGP_LPJ_G0026273	protein coding gene	Chr2:122270696-122282151 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026153	protein coding gene	Chr2:134754241-134767153 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026813	protein coding gene	Chr2:120390164-120403230 (-)
PWK/PhJ	MGP_PWKPhJ_G0025255	protein coding gene	Chr2:115978627-115991333 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025054	protein coding gene	Chr2:119578230-119593185 (-)
WSB/EiJ	MGP_WSBEiJ_G0025588	protein coding gene	Chr2:121226118-121240274 (-)

Human Ortholog

PPP1R14D, protein phosphatase 1 regulatory inhibitor subunit 14D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R14D, protein phosphatase 1 regulatory inhibitor subunit 14D
Synonyms

CPI17-like, GBPI-1, GBPI1
Links

HGNC:14953

NCBI Gene ID: 54866

neXtProt AC: NX_Q9NXH3

UniProt: Q9NXH3
Chr Location

15q15.1; chr15:40815451-40828709 (-) GRCh38

MGI Vertebrate Homology

Ppp1r14d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP1R14D
Gene Tree

Ppp1r14d

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Ppp1r14d
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

8
UniProt

1
CCDS

CCDS16596.1, CCDS71118.1

Ensembl

ENSMUSG00000027317 (Evidence)
NCBI Gene

72112

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027317	Ensembl Gene Model \| MGI Sequence Detail	11788	C57BL/6J	± kb
transcript	ENSMUST00000110820	Ensembl \| MGI Sequence Detail	790	Not Applicable
polypeptide	ENSMUSP00000106444	Ensembl \| MGI Sequence Detail	175	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013115 protein phosphatase 1 regulatory subunit 14D

(term hierarchy)
InterPro Domains

IPR008025 CPI-17

IPR036658 CPI-17 superfamily

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All nucleic 4

cDNA 4

Microarray probesets 2

Summaries

All 34

Gene Ontology 5

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp1r14d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25808	Chr2:119060872-119060883 (-)	-491 bp
Tssr25807	Chr2:119060395-119060407 (-)	-14 bp
Tssr25806	Chr2:119060366-119060394 (-)	7 bp
Tssr25805	Chr2:119060330-119060358 (-)	43 bp
Tssr25804	Chr2:119060309-119060325 (-)	70 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24