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Zdhhc17 Gene Detail
Summary
  • Symbol
    Zdhhc17
  • Name
    zinc finger, DHHC domain containing 17
  • Synonyms
    A230053P19Rik, D130071N24Rik, Hip14, mKIAA0946
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445110
    NCBI Gene: 320150
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:110777641-110846001 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 57.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1722 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445110
 protein coding gene Chr10:110777640-110848587 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017718
 protein coding gene Chr10:113308786-113377051 (-)
A/J MGP_AJ_G0017695
 protein coding gene Chr10:109012806-109078811 (-)
AKR/J MGP_AKRJ_G0017657
 protein coding gene Chr10:112194103-112262950 (-)
BALB/cJ MGP_BALBcJ_G0017659
 protein coding gene Chr10:109413687-109479876 (-)
C3H/HeJ MGP_C3HHeJ_G0017484
 protein coding gene Chr10:112331779-112401973 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018116
 protein coding gene Chr10:117237583-117308227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015795
 protein coding gene Chr10:103887042-103949156 (-)
CAST/EiJ MGP_CASTEiJ_G0017045
 protein coding gene Chr10:112496045-112564486 (-)
CBA/J MGP_CBAJ_G0017453
 protein coding gene Chr10:121807912-121887789 (-)
DBA/2J MGP_DBA2J_G0017558
 protein coding gene Chr10:108143141-108216838 (-)
FVB/NJ MGP_FVBNJ_G0017552
 protein coding gene Chr10:107148469-107217512 (-)
LP/J MGP_LPJ_G0017632
 protein coding gene Chr10:113947961-114022178 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017581
 protein coding gene Chr10:124522549-124591918 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018154
 protein coding gene Chr10:112204470-112277538 (-)
PWK/PhJ MGP_PWKPhJ_G0016827
 protein coding gene Chr10:108233863-108299293 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016617
 protein coding gene Chr10:110974986-111039798 (-)
WSB/EiJ MGP_WSBEiJ_G0017105
 protein coding gene Chr10:112347681-112416317 (-)



Homology
more
  • Human Ortholog
    ZDHHC17, zinc finger DHHC-type palmitoyltransferase 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC17, zinc finger DHHC-type palmitoyltransferase 17
  • Synonyms
    DHHC-17, DHHC17, HIP14, HIP3, HSPC294, HYPH
  • Links
    NCBI Gene ID: 23390
    neXtProt AC: NX_Q8IUH5
    UniProt: Q8IUH5

  • Chr Location
    12q21.2; chr12:76764103-76853701 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zdhhc17 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reminiscent of Huntington disease (decreased body weight, impaired coordination, hyperactivity, increased rearing, decreased prepulse inhibition, increased stereotypic behavior, reduced striatum, and decreased brain weight).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    29
  • cDNA Data
    87
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035798 Ensembl Gene Model | MGI Sequence Detail 68361 C57BL/6J ±  kb
    transcript ENSMUST00000041723 Ensembl | MGI Sequence Detail 4548 Not Applicable  
    polypeptide ENSMUSP00000043279 Ensembl | MGI Sequence Detail 632 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 87
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143904, MGI:2443485
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 14
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345690 Gupta JP, et al., Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel Na(V)1.2 in neurons. Front Physiol. 2023;14:959660
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory