Dcaf1 MGI Mouse Gene Detail - MGI:2445220 - DDB1 and CUL4 associated factor 1

Symbol

Dcaf1
Name

DDB1 and CUL4 associated factor 1
Synonyms

B930007L02Rik, Vprbp

Feature Type

protein coding gene
IDs

MGI:2445220
NCBI Gene: 321006
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:106699073-106758191 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 57.98 cM
Mapping Data

2 experiments

SNPs within 2kb

959 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445220	protein coding gene	Chr9:106691354-106758191 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035244	protein coding gene	Chr9:108663580-108731219 (+)
A/J	MGP_AJ_G0035223	protein coding gene	Chr9:104718851-104782298 (+)
AKR/J	MGP_AKRJ_G0035155	protein coding gene	Chr9:107324267-107384647 (+)
BALB/cJ	MGP_BALBcJ_G0035217	protein coding gene	Chr9:104404096-104462750 (+)
C3H/HeJ	MGP_C3HHeJ_G0034927	protein coding gene	Chr9:107742753-107801814 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035737	protein coding gene	Chr9:111646418-111710452 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032635	protein coding gene	Chr9:102199513-102258180 (+)
CAST/EiJ	MGP_CASTEiJ_G0034238	protein coding gene	Chr9:107665503-107728991 (+)
CBA/J	MGP_CBAJ_G0034895	protein coding gene	Chr9:115624426-115686581 (+)
DBA/2J	MGP_DBA2J_G0035056	protein coding gene	Chr9:104175342-104236842 (+)
FVB/NJ	MGP_FVBNJ_G0035004	protein coding gene	Chr9:102959242-103020253 (+)
LP/J	MGP_LPJ_G0035132	protein coding gene	Chr9:108874615-108935378 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035043	protein coding gene	Chr9:117176120-117242183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035758	protein coding gene	Chr9:107593700-107658336 (+)
PWK/PhJ	MGP_PWKPhJ_G0033945	protein coding gene	Chr9:104493222-104552623 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033780	protein coding gene	Chr9:107669915-107734299 (+)
WSB/EiJ	MGP_WSBEiJ_G0034359	protein coding gene	Chr9:107500926-107562479 (+)

Human Ortholog

DCAF1, DDB1 and CUL4 associated factor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF1, DDB1 and CUL4 associated factor 1
Synonyms

RIP, VPRBP
Links

HGNC:30911

NCBI Gene ID: 9730

neXtProt AC: NX_Q9Y4B6

UniProt: Q9Y4B6
Chr Location

3p21.2; chr3:51395867-51505639 (-) GRCh38

MGI Vertebrate Homology

Dcaf1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DCAF1
Gene Tree

Dcaf1

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

1
Gene trapped

21
Targeted

4
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available

Embryos homozygous for a knock-out allele die prior to E7.5.

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All GO Annotations

39
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf1

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All Sequences

58
RefSeq

15
UniProt

2
CCDS

CCDS23485.1, CCDS90657.1

Ensembl

ENSMUSG00000040325 (Evidence)
NCBI Gene

321006

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040325	Ensembl Gene Model \| MGI Sequence Detail	59119	C57BL/6J	± kb
transcript	ENSMUST00000161758	Ensembl \| MGI Sequence Detail	5539	Not Applicable
polypeptide	ENSMUSP00000125730	Ensembl \| MGI Sequence Detail	1512	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017316 DDB1- and CUL4-associated factor 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR006594 LIS1 homology motif

IPR033270 VPRBP/DCAF1 family

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q80TR8 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGI:2147535, MGI:5906190

Summaries

All 50

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 18
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:305161 Dar AA, et al., The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA. PLoS Biol. 2021 Feb;19(2):e3001041

TSS for Dcaf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86935	Chr9:106699093-106699193 (+)	70 bp
Tssr86936	Chr9:106699198-106699215 (+)	134 bp
Tssr86937	Chr9:106699222-106699233 (+)	155 bp
Tssr86938	Chr9:106716897-106716900 (+)	17,826 bp
Tssr86939	Chr9:106755136-106755138 (+)	56,064 bp
Tssr86940	Chr9:106757308-106757330 (+)	58,246 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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