Dnajc6 MGI Mouse Gene Detail - MGI:1919935 - DnaJ heat shock protein family (Hsp40) member C6

Symbol

Dnajc6
Name

DnaJ heat shock protein family (Hsp40) member C6
Synonyms

2810027M23Rik, auxilin, mKIAA0473

Feature Type

protein coding gene
IDs

MGI:1919935
NCBI Gene: 72685
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr4:101353828-101499996 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 46.89 cM
Mapping Data

1 experiment

SNPs within 2kb

4422 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919935	protein coding gene	Chr4:101353751-101499996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028493	protein coding gene	Chr4:101807142-101959945 (+)
A/J	MGP_AJ_G0028456	protein coding gene	Chr4:98245470-98393606 (+)
AKR/J	MGP_AKRJ_G0028403	protein coding gene	Chr4:100621947-100773153 (+)
BALB/cJ	MGP_BALBcJ_G0028474	protein coding gene	Chr4:98463068-98609916 (+)
C3H/HeJ	MGP_C3HHeJ_G0028187	protein coding gene	Chr4:101421257-101573190 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028913	protein coding gene	Chr4:105651171-105808532 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026205	protein coding gene	Chr4:93515986-93662868 (+)
CAST/EiJ	MGP_CASTEiJ_G0027627	protein coding gene	Chr4:99200713-99362362 (+)
CBA/J	MGP_CBAJ_G0028156	protein coding gene	Chr4:108973193-109133469 (+)
DBA/2J	MGP_DBA2J_G0028306	protein coding gene	Chr4:97937832-98088312 (+)
FVB/NJ	MGP_FVBNJ_G0028273	protein coding gene	Chr4:96780019-96927132 (+)
LP/J	MGP_LPJ_G0028406	protein coding gene	Chr4:102111898-102265221 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028301	protein coding gene	Chr4:114519080-114669622 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028951	protein coding gene	Chr4:100874544-101035113 (+)
PWK/PhJ	MGP_PWKPhJ_G0027352	protein coding gene	Chr4:96113989-96264414 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027174	protein coding gene	Chr4:98326213-98479703 (+)
WSB/EiJ	MGP_WSBEiJ_G0027705	protein coding gene	Chr4:101042991-101193987 (+)

Human Ortholog

DNAJC6, DnaJ heat shock protein family (Hsp40) member C6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC6, DnaJ heat shock protein family (Hsp40) member C6
Synonyms

DJC6, PARK19
Links

HGNC:15469

NCBI Gene ID: 9829

neXtProt AC: NX_O75061

UniProt: O75061
Chr Location

1p31.3; chr1:65248219-65415871 (+) GRCh38

MGI Vertebrate Homology

Dnajc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJC6
Gene Tree

Dnajc6

Diseases

2 with human DNAJC6 associations

				Human Disease	Mouse Models
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				Parkinson's disease 19A IDs Parkinson's disease 19A DOID:0060891 ICD10CM:G20 OMIM:615528 ORDO:391411

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
4 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Dnajc6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous and heterozygous for a knock-out allele exhibit postnatal lethality and decreased body weight with homozygotes exhibiting decreased synpatic vesicle recycling.

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All GO Annotations

33
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1022
Tissues

35
cDNA Data

49
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc6

ZFIN dnajc6

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All Sequences

68
RefSeq

12
UniProt

3
CCDS

CCDS18395.1, CCDS51237.1, CCDS51238.1

Ensembl

ENSMUSG00000028528 (Evidence)
NCBI Gene

72685

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028528	Ensembl Gene Model \| MGI Sequence Detail	146169	C57BL/6J	± kb
transcript	ENSMUST00000106933	Ensembl \| MGI Sequence Detail	5191	Not Applicable
polypeptide	ENSMUSP00000102546	Ensembl \| MGI Sequence Detail	968	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030384 putative tyrosine-protein phosphatase auxilin

(term hierarchy)
EC

3.1.3.-
InterPro Domains

IPR035892 C2 domain superfamily

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR051281 Dual-specificity lipid and protein phosphatase

IPR029021 Protein-tyrosine phosphatase-like

IPR014020 Tensin phosphatase, C2 domain

IPR029023 Tensin-type phosphatase domain

IPR000387 Tyrosine-specific protein phosphatases domain
GlyGen

Q80TZ3 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 49

cDNA 49

Microarray probesets 4

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 20
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnajc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37995	Chr4:101353742-101353795 (+)	-59 bp
Tssr37996	Chr4:101353873-101353919 (+)	68 bp
Tssr37997	Chr4:101364674-101364692 (+)	10,855 bp
Tssr37998	Chr4:101364958-101364969 (+)	11,136 bp
Tssr37999	Chr4:101364981-101364997 (+)	11,161 bp
Tssr38000	Chr4:101365052-101365065 (+)	11,231 bp
Tssr38001	Chr4:101365128-101365138 (+)	11,305 bp
Tssr38002	Chr4:101365144-101365229 (+)	11,359 bp
Tssr38003	Chr4:101365296-101365327 (+)	11,484 bp
Tssr38004	Chr4:101407496-101407524 (+)	53,682 bp
Tssr38005	Chr4:101407537-101407571 (+)	53,726 bp
Tssr38006	Chr4:101407574-101407595 (+)	53,757 bp
Tssr38007	Chr4:101407608-101407629 (+)	53,791 bp
Tssr38008	Chr4:101407996-101408021 (+)	54,181 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24