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Gpr139 Gene Detail
Summary
  • Symbol
    Gpr139
  • Name
    G protein-coupled receptor 139
  • Synonyms
    GPRg1, LOC209776
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685341
    NCBI Gene: 209776
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118739970-118783761 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.79 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    981 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685341
 protein coding gene Chr7:118739970-118783826 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032908
 protein coding gene Chr7:123033164-123075156 (-)
A/J MGP_AJ_G0032891
 protein coding gene Chr7:119885630-119925635 (-)
AKR/J MGP_AKRJ_G0032823
 protein coding gene Chr7:122967059-123007097 (-)
BALB/cJ MGP_BALBcJ_G0032896
 protein coding gene Chr7:119611199-119651203 (-)
C3H/HeJ MGP_C3HHeJ_G0032606
 protein coding gene Chr7:122854603-122894544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033402
 protein coding gene Chr7:127917825-127963978 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030374
 protein coding gene Chr7:121315827-121355824 (-)
CAST/EiJ MGP_CASTEiJ_G0031934
 protein coding gene Chr7:114635092-114675004 (-)
CBA/J MGP_CBAJ_G0032579
 protein coding gene Chr7:132212599-132254441 (-)
DBA/2J MGP_DBA2J_G0032731
 protein coding gene Chr7:117923554-117963561 (-)
FVB/NJ MGP_FVBNJ_G0032684
 protein coding gene Chr7:117768018-117808444 (-)
LP/J MGP_LPJ_G0032825
 protein coding gene Chr7:124506090-124545905 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032716
 protein coding gene Chr7:133674776-133716036 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033422
 protein coding gene Chr7:121954086-121994088 (-)
PWK/PhJ MGP_PWKPhJ_G0031642
 protein coding gene Chr7:110837339-110878242 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031489
 protein coding gene Chr7:108685720-108725673 (-)
WSB/EiJ MGP_WSBEiJ_G0032047
 protein coding gene Chr7:122843748-122883806 (-)



Homology
more
  • Human Ortholog
    GPR139, G protein-coupled receptor 139
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR139, G protein-coupled receptor 139
  • Synonyms
    GPRg1, PGR3
  • Links
    NCBI Gene ID: 124274
    neXtProt AC: NX_Q6DWJ6
    UniProt: Q6DWJ6

  • Chr Location
    16p12.3; chr16:20028239-20073890 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced opioid-induced inhibition of neuronal firing and increased morphine-induced analgesia with augmented reward effects but decreased behavioral withdrawal responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    41
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 209776 NCBI Gene Model | MGI Sequence Detail 43792 C57BL/6J ±  kb
transcript NM_001024138 RefSeq | MGI Sequence Detail 4778 C57BL/6  
polypeptide Q80UC8 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 7
    Primer pair 1
    Other 2

    Microarray probesets 1
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory