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Wnk4 Gene Detail
Summary
  • Symbol
    Wnk4
  • Name
    WNK lysine deficient protein kinase 4
  • Synonyms
    2010002J11Rik, Prkwnk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917097
    NCBI Gene: 69847
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101151393-101168235 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    400 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917097
 protein coding gene Chr11:101151363-101168235 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019190
 protein coding gene Chr11:104103709-104120561 (+)
A/J MGP_AJ_G0019158
 protein coding gene Chr11:99727653-99744394 (+)
AKR/J MGP_AKRJ_G0019127
 protein coding gene Chr11:102824755-102845183 (+)
BALB/cJ MGP_BALBcJ_G0019132
 protein coding gene Chr11:100214029-100231348 (+)
C3H/HeJ MGP_C3HHeJ_G0018941
 protein coding gene Chr11:102998795-103019455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019581
 protein coding gene Chr11:107341352-107371089 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017207
 protein coding gene Chr11:97141106-97157752 (+)
CAST/EiJ MGP_CASTEiJ_G0018495
 protein coding gene Chr11:103987629-104007864 (+)
CBA/J MGP_CBAJ_G0018910
 protein coding gene Chr11:111785216-111810605 (+)
DBA/2J MGP_DBA2J_G0019022
 protein coding gene Chr11:99254579-99273515 (+)
FVB/NJ MGP_FVBNJ_G0019012
 protein coding gene Chr11:98801325-98819754 (+)
LP/J MGP_LPJ_G0019091
 protein coding gene Chr11:104648668-104665570 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019043
 protein coding gene Chr11:111347324-111366095 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019619
 protein coding gene Chr11:103154362-103172281 (+)
PWK/PhJ MGP_PWKPhJ_G0018258
 protein coding gene Chr11:100310831-100327953 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018050
 protein coding gene Chr11:102891607-102910258 (+)
WSB/EiJ MGP_WSBEiJ_G0018544
 protein coding gene Chr11:103147399-103168554 (+)



Homology
more
  • Human Ortholog
    WNK4, WNK lysine deficient protein kinase 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNK4, WNK lysine deficient protein kinase 4
  • Synonyms
    PHA2B, PRKWNK4
  • Links
    NCBI Gene ID: 65266
    neXtProt AC: NX_Q96J92
    UniProt: Q96J92

  • Chr Location
    17q21.2; chr17:42780610-42797066 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Wnk4 mouse models; 2 with human WNK4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 7 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    47
  • cDNA Data
    26
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035112 Ensembl Gene Model | MGI Sequence Detail 16843 C57BL/6J ±  kb
    transcript ENSMUST00000103108 Ensembl | MGI Sequence Detail 4117 Not Applicable  
    polypeptide ENSMUSP00000099397 Ensembl | MGI Sequence Detail 1222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 3
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 42
      Phenotypes 40
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory