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Ticam1 Gene Detail
Summary
  • Symbol
    Ticam1
  • Name
    TIR domain containing adaptor molecule 1
  • Synonyms
    TICAM-1, Trif
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147032
    NCBI Gene: 106759
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56576462-56583767 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147032
 protein coding gene Chr17:56576319-56583786 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023921
 protein coding gene Chr17:57942381-57955527 (-)
A/J MGP_AJ_G0023879
 protein coding gene Chr17:56366413-56373948 (-)
AKR/J MGP_AKRJ_G0023848
 protein coding gene Chr17:57051015-57060146 (-)
BALB/cJ MGP_BALBcJ_G0023880
 protein coding gene Chr17:56188971-56196410 (-)
C3H/HeJ MGP_C3HHeJ_G0023644
 protein coding gene Chr17:57766476-57774925 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024326
 protein coding gene Chr17:60214349-60224818 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021772
 protein coding gene Chr17:52856195-52863475 (-)
CAST/EiJ MGP_CASTEiJ_G0023126
 protein coding gene Chr17:58065766-58075122 (-)
CBA/J MGP_CBAJ_G0023620
 protein coding gene Chr17:62543097-62554426 (-)
DBA/2J MGP_DBA2J_G0023748
 protein coding gene Chr17:55076754-55084659 (-)
FVB/NJ MGP_FVBNJ_G0023714
 protein coding gene Chr17:54608152-54615600 (-)
LP/J MGP_LPJ_G0023830
 protein coding gene Chr17:58632679-58642420 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023742
 protein coding gene Chr17:62059155-62067359 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024370
 protein coding gene Chr17:57422830-57431992 (-)
PWK/PhJ MGP_PWKPhJ_G0022872
 protein coding gene Chr17:54427175-54434579 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022683
 protein coding gene Chr17:54182438-54189666 (-)
WSB/EiJ MGP_WSBEiJ_G0023192
 protein coding gene Chr17:58027603-58035019 (-)



Homology
more
  • Human Ortholog
    TICAM1, TIR domain containing adaptor molecule 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TICAM1, TIR domain containing adaptor molecule 1
  • Synonyms
    IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
  • Links
    NCBI Gene ID: 148022
    neXtProt AC: NX_Q8IUC6
    UniProt: Q8IUC6

  • Chr Location
    19p13.3; chr19:4815932-4831712 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TICAM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 5 alleles in 9 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    615 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable but exhibit abnormalities of the innate immune system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    23
  • cDNA Data
    44
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106759 NCBI Gene Model | MGI Sequence Detail 7306 C57BL/6J ±  kb
    transcript NM_174989 RefSeq | MGI Sequence Detail 2830 C57BL/6  
    polypeptide Q80UF7 UniProt | EBI | MGI Sequence Detail 732 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000001749 TIR domain-containing adapter molecule 1
      (term hierarchy)
    • InterPro Domains
      IPR025735 RHIM domain
      IPR017278 TIR domain-containing adapter molecule 1
      IPR046946 TIR domain-containing adapter molecule 1/2
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
      IPR040886 TRIF, N-terminal
    • GlyGen
      Q80UF7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 44
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147076
    References
    more
    • Summaries
      All 716
      Developmental Gene Expression 5
      Gene Ontology 22
      Phenotypes 615
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:352683 Purbey PK, et al., Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity. Cell Rep. 2024 Jun 25;43(6):114289
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory