Polr2e MGI Mouse Gene Detail - MGI:1913670 - polymerase (RNA) II (DNA directed) polypeptide E

Symbol

Polr2e
Name

polymerase (RNA) II (DNA directed) polypeptide E
Synonyms

25kDa, RPB5, XAP4

Feature Type

protein coding gene
IDs

MGI:1913670
NCBI Gene: 66420
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:79871787-79875493 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

199 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913670	protein coding gene	Chr10:79871783-79875629 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017479	protein coding gene	Chr10:80611135-80614981 (-)
A/J	MGP_AJ_G0017457	protein coding gene	Chr10:77793482-77797328 (-)
AKR/J	MGP_AKRJ_G0017418	protein coding gene	Chr10:79914555-79918401 (-)
BALB/cJ	MGP_BALBcJ_G0017419	protein coding gene	Chr10:78020188-78024034 (-)
C3H/HeJ	MGP_C3HHeJ_G0017242	protein coding gene	Chr10:80018954-80022800 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017873	protein coding gene	Chr10:83394427-83398273 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015561	protein coding gene	Chr10:74018860-74023125 (-)
CAST/EiJ	MGP_CASTEiJ_G0016809	protein coding gene	Chr10:80216425-80220265 (-)
CBA/J	MGP_CBAJ_G0017214	protein coding gene	Chr10:86623399-86627245 (-)
DBA/2J	MGP_DBA2J_G0017320	protein coding gene	Chr10:77008646-77012492 (-)
FVB/NJ	MGP_FVBNJ_G0017314	protein coding gene	Chr10:76189256-76193102 (-)
LP/J	MGP_LPJ_G0017391	protein coding gene	Chr10:81087684-81091530 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017340	protein coding gene	Chr10:88581804-88585650 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017914	protein coding gene	Chr10:79898708-79902554 (-)
PWK/PhJ	MGP_PWKPhJ_G0016590	protein coding gene	Chr10:76875809-76879689 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016379	protein coding gene	Chr10:78873729-78877841 (-)
WSB/EiJ	MGP_WSBEiJ_G0016869	protein coding gene	Chr10:79926580-79930426 (-)

Human Ortholog

POLR2E, RNA polymerase II, I and III subunit E

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLR2E, RNA polymerase II, I and III subunit E
Synonyms

hRPB25, hsRPB5, RPABC1, RPB5, XAP4
Links

HGNC:9192

NCBI Gene ID: 5434

neXtProt AC: NX_P19388

UniProt: P19388
Chr Location

19p13.3; chr19:1086574-1095380 (-) GRCh38

MGI Vertebrate Homology

Polr2e stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: POLR2E
Protein SuperFamily

RPB5
Gene Tree

Polr2e

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

43
Chemically induced (other)

1
Gene trapped

41
Targeted

1
Genomic Mutations

1 involving Polr2e
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

867
Tissues

129
cDNA Data

151
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polr2e

ZFIN polr2eb

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All Sequences

49
RefSeq

2
UniProt

5
CCDS

CCDS35972.1

Ensembl

ENSMUSG00000004667 (Evidence)
NCBI Gene

66420

			Length	Strain/Species	Flank
genomic	66420	NCBI Gene Model \| MGI Sequence Detail	3707	C57BL/6J	± kb
transcript	NM_025554	RefSeq \| MGI Sequence Detail	1022	FVB/N
polypeptide	Q80UW8	UniProt \| EBI \| MGI Sequence Detail	210	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012991 DNA-directed RNA polymerases I, II, and III subunit RPABC1

(term hierarchy)
InterPro Domains

IPR014381 DNA-directed RNA polymerase subunit Rpo5/Rpb5

IPR005571 RNA polymerase, Rpb5, N-terminal

IPR036710 RNA polymerase Rpb5, N-terminal domain superfamily

IPR020608 RNA polymerase, subunit H/Rpb5, conserved site

IPR000783 RNA polymerase, subunit H/Rpb5 C-terminal

IPR035913 RPB5-like RNA polymerase subunit superfamily
GlyGen

Q80UW8 1 site, 1 N-linked glycan (1 site)

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All nucleic 152

cDNA 151

Primer pair 1

Microarray probesets 5

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MGI:2143824

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754

TSS for Polr2e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98380	Chr10:79875508-79875558 (-)	-40 bp
Tssr98379	Chr10:79875479-79875506 (-)	0 bp
Tssr98378	Chr10:79872589-79872600 (-)	2,898 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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