Carnmt1 MGI Mouse Gene Detail - MGI:1914633 - carnosine N-methyltransferase 1

Symbol

Carnmt1
Name

carnosine N-methyltransferase 1
Synonyms

2410127L17Rik

Feature Type

protein coding gene
IDs

MGI:1914633
NCBI Gene: 67383
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:18648128-18684564 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 13.18 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

1095 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914633	protein coding gene	Chr19:18648099-18684565 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024968	protein coding gene	Chr19:16550877-16586771 (+)
A/J	MGP_AJ_G0024945	protein coding gene	Chr19:15619902-15654114 (+)
AKR/J	MGP_AKRJ_G0024915	protein coding gene	Chr19:16238872-16274147 (+)
BALB/cJ	MGP_BALBcJ_G0024944	protein coding gene	Chr19:15651366-15685831 (+)
C3H/HeJ	MGP_C3HHeJ_G0024702	protein coding gene	Chr19:16181815-16216781 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025386	protein coding gene	Chr19:17141214-17180668 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022805	protein coding gene	Chr19:15991004-16022913 (+)
CAST/EiJ	MGP_CASTEiJ_G0024170	protein coding gene	Chr19:15818973-15857946 (+)
CBA/J	MGP_CBAJ_G0024680	protein coding gene	Chr19:17764940-17804094 (+)
DBA/2J	MGP_DBA2J_G0024812	protein coding gene	Chr19:15648476-15683903 (+)
FVB/NJ	MGP_FVBNJ_G0024773	protein coding gene	Chr19:15565920-15599649 (+)
LP/J	MGP_LPJ_G0024896	protein coding gene	Chr19:16521900-16557709 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024800	protein coding gene	Chr19:17636085-17680922 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025441	protein coding gene	Chr19:16176701-16214444 (+)
PWK/PhJ	MGP_PWKPhJ_G0023919	protein coding gene	Chr19:15194158-15229736 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023724	protein coding gene	Chr19:15464897-15503796 (+)
WSB/EiJ	MGP_WSBEiJ_G0024238	protein coding gene	Chr19:16223653-16259256 (+)

Human Ortholog

CARNMT1, carnosine N-methyltransferase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CARNMT1, carnosine N-methyltransferase 1
Synonyms

C9orf41, UPF0586
Links

HGNC:23435

NCBI Gene ID: 138199

neXtProt AC: NX_Q8N4J0

UniProt: Q8N4J0
Chr Location

9q21.13; chr9:74980790-75028430 (-) GRCh38

MGI Vertebrate Homology

Carnmt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CARNMT1
Gene Tree

Carnmt1

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

3
Gene trapped

48
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available

Micr homozygous for a null or catalytically inactive allele die between E13.5 and E15.5.

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

9
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase carnmt1

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All Sequences

57
RefSeq

14
UniProt

2
CCDS

CCDS29689.1

Ensembl

ENSMUSG00000024726 (Evidence)
NCBI Gene

67383

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024726	Ensembl Gene Model \| MGI Sequence Detail	36437	C57BL/6J	± kb
transcript	ENSMUST00000025632	Ensembl \| MGI Sequence Detail	4518	Not Applicable
polypeptide	ENSMUSP00000025632	Ensembl \| MGI Sequence Detail	400	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060157 carnosine N-methyltransferase

(term hierarchy)
EC

2.1.1.22
InterPro Domains

IPR012901 Carnosine N-methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 7

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:341536 Shimazu T, et al., Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism. Genes Dev. 2023 Aug 1;37(15-16):724-742

TSS for Carnmt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155445	Chr19:18648088-18648143 (+)	-12 bp
Tssr155446	Chr19:18648144-18648174 (+)	31 bp
Tssr155447	Chr19:18648176-18648213 (+)	67 bp
Tssr155448	Chr19:18648272-18648292 (+)	154 bp
Tssr5455	Chr19:18648304-18648314 (+)	181 bp
Tssr155449	Chr19:18648554-18648565 (+)	432 bp
Tssr155450	Chr19:18658606-18658607 (+)	10,479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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