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Trnau1ap Gene Detail
Summary
  • Symbol
    Trnau1ap
  • Name
    tRNA selenocysteine 1 associated protein 1
  • Synonyms
    1110007F05Rik, SECp43, Trspap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919037
    NCBI Gene: 71787
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132039074-132056849 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.16 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    649 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919037
 protein coding gene Chr4:132039074-132058007 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028868
 protein coding gene Chr4:134451603-134472279 (-)
A/J MGP_AJ_G0028827
 protein coding gene Chr4:128867580-128886070 (-)
AKR/J MGP_AKRJ_G0028780
 protein coding gene Chr4:132486890-132504916 (-)
BALB/cJ MGP_BALBcJ_G0028850
 protein coding gene Chr4:129477591-129496704 (-)
C3H/HeJ MGP_C3HHeJ_G0028564
 protein coding gene Chr4:132743623-132763397 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029292
 protein coding gene Chr4:139306621-139325111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026563
 protein coding gene Chr4:121944393-121962740 (-)
CAST/EiJ MGP_CASTEiJ_G0027997
 protein coding gene Chr4:130819061-130838238 (-)
CBA/J MGP_CBAJ_G0028530
 protein coding gene Chr4:142879310-142897101 (-)
DBA/2J MGP_DBA2J_G0028679
 protein coding gene Chr4:129290851-129308769 (-)
FVB/NJ MGP_FVBNJ_G0028646
 protein coding gene Chr4:128138753-128157274 (-)
LP/J MGP_LPJ_G0028780
 protein coding gene Chr4:134610340-134629299 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028672
 protein coding gene Chr4:147470380-147490118 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029330
 protein coding gene Chr4:132891576-132909198 (-)
PWK/PhJ MGP_PWKPhJ_G0027718
 protein coding gene Chr4:125970052-125988550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027544
 protein coding gene Chr4:128762772-128781431 (-)
WSB/EiJ MGP_WSBEiJ_G0028077
 protein coding gene Chr4:133076576-133095160 (-)



Homology
more
  • Human Ortholog
    TRNAU1AP, tRNA selenocysteine 1 associated protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRNAU1AP, tRNA selenocysteine 1 associated protein 1
  • Synonyms
    PRO1902, SECP43, TRSPAP1
  • Links
    NCBI Gene ID: 54952
    neXtProt AC: NX_Q9NX07
    UniProt: Q9NX07

  • Chr Location
    1p35.3; chr1:28553085-28578545 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an allele lacking exons 7 and 8 exhibit prenatal lethality. Mice homozygous for a conditional allele activated in neurons exhibit impaired performance on a rotarod.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    41
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028898 Ensembl Gene Model | MGI Sequence Detail 17776 C57BL/6J ±  kb
transcript ENSMUST00000030730 Ensembl | MGI Sequence Detail 1130 Not Applicable  
polypeptide ENSMUSP00000030730 Ensembl | MGI Sequence Detail 287 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000016687 tRNA selenocysteine 1-associated protein 1
    (term hierarchy)
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR034510 SECp43, RNA recognition motif 2
    IPR040434 tRNA selenocysteine 1-associated protein 1
    IPR041085 tRNA selenocysteine 1-associated protein 1, C-terminal
Molecular
Reagents
less
  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:3034225
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:237714 Mahdi Y, et al., Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap). PLoS One. 2015;10(6):e0127349
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory