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Zfp74 Gene Detail
Summary
  • Symbol
    Zfp74
  • Name
    zinc finger protein 74
  • Synonyms
    2810054M15Rik, KRAB8, Zfp66
  • Feature Type
    protein coding gene
  • IDs
    MGI:107784
    NCBI Gene: 72723
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:29632086-29653579 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    851 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107784
 protein coding gene Chr7:29630240-29653579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031993
 protein coding gene Chr7:28868240-28891761 (-)
A/J MGP_AJ_G0031970
 protein coding gene Chr7:28131974-28157627 (-)
AKR/J MGP_AKRJ_G0031903
 protein coding gene Chr7:28833462-28858586 (-)
BALB/cJ MGP_BALBcJ_G0031977
 protein coding gene Chr7:28305246-28330346 (-)
C3H/HeJ MGP_C3HHeJ_G0031696
 protein coding gene Chr7:29285382-29309996 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032442
 protein coding gene Chr7:29793029-29819271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029493
 protein coding gene Chr7:29167876-29195548 (-)
CAST/EiJ MGP_CASTEiJ_G0031030
 protein coding gene Chr7:22522072-22548763 (-)
CBA/J MGP_CBAJ_G0031662
 protein coding gene Chr7:31235310-31261462 (-)
DBA/2J MGP_DBA2J_G0031814
 protein coding gene Chr7:27857305-27882706 (-)
FVB/NJ MGP_FVBNJ_G0031771
 protein coding gene Chr7:27969672-27993335 (-)
LP/J MGP_LPJ_G0031895
 protein coding gene Chr7:29205552-29231913 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031807
 protein coding gene Chr7:30529657-30555834 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032471
 protein coding gene Chr7:28329475-28355064 (-)
PWK/PhJ MGP_PWKPhJ_G0030756
 protein coding gene Chr7:22882585-22908555 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030589
 protein coding gene Chr7:19337987-19361229 (-)
WSB/EiJ MGP_WSBEiJ_G0031140
 protein coding gene Chr7:28723445-28745808 (-)



Homology
more
  • Human Ortholog
    ZNF569, zinc finger protein 569
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF569, zinc finger protein 569
  • Synonyms
    ZAP1, Zfp74, ZNF
  • Links
    NCBI Gene ID: 148266
    neXtProt AC: NX_Q5MCW4
    UniProt: Q5MCW4

  • Chr Location
    19q13.12; chr19:37411155-37469275 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    25
  • cDNA Data
    38
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72723 NCBI Gene Model | MGI Sequence Detail 21494 C57BL/6J ±  kb
transcript NM_178384 RefSeq | MGI Sequence Detail 3919 ZRU/MplStud  
polypeptide Q80W31 UniProt | EBI | MGI Sequence Detail 679 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36361, MGI:1919973
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:29678 Bellefroid EJ, et al., Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10757-61
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory