Gadl1 Gene Detail

Summary

• Symbol
  Gadl1
• Name
  glutamate decarboxylase-like 1
• Synonyms
  1110027M19Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1920998
  NCBI Gene: 73748
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr9:115713947-115905243 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 68.25 cM, cytoband F3
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  6334 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920998	protein coding gene	Chr9:115713739-115905244 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035399	protein coding gene	Chr9:118475278-118642177 (+)
A/J	MGP_AJ_G0035379	protein coding gene	Chr9:114102467-114246808 (+)
AKR/J	MGP_AKRJ_G0035312	protein coding gene	Chr9:117035854-117188379 (+)
BALB/cJ	MGP_BALBcJ_G0035375	protein coding gene	Chr9:113903251-114047187 (+)
C3H/HeJ	MGP_C3HHeJ_G0035083	protein coding gene	Chr9:117544194-117695069 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035898	protein coding gene	Chr9:121713845-121862610 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032781	protein coding gene	Chr9:111344866-111514334 (+)
CAST/EiJ	MGP_CASTEiJ_G0034388	protein coding gene	Chr9:117399660-117581602 (+)
CBA/J	MGP_CBAJ_G0035050	protein coding gene	Chr9:126263485-126427824 (+)
DBA/2J	MGP_DBA2J_G0035209	protein coding gene	Chr9:113586206-113728284 (+)
FVB/NJ	MGP_FVBNJ_G0035156	protein coding gene	Chr9:112413338-112562830 (+)
LP/J	MGP_LPJ_G0035288	protein coding gene	Chr9:118809341-118970334 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035197	protein coding gene	Chr9:127448834-127601131 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035917	protein coding gene	Chr9:117406873-117562140 (+)
PWK/PhJ	MGP_PWKPhJ_G0034094	protein coding gene	Chr9:113893882-114048359 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033928	protein coding gene	Chr9:117447415-117628909 (+)
WSB/EiJ	MGP_WSBEiJ_G0034508	protein coding gene	Chr9:117296008-117448916 (+)

Homology

• Human Ortholog
  GADL1, glutamate decarboxylase like 1

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GADL1, glutamate decarboxylase like 1
  
• Synonyms
  ADC, CSADC, HuADC, HuCSADC
• Links
  HGNC:27949

  NCBI Gene ID: 339896

  neXtProt AC: NX_Q6ZQY3

  UniProt: Q6ZQY3

  
  
• Chr Location
  3p24.1-p23; chr3:30726197-30894661 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gadl1 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: GADL1
• Gene Tree
  Gadl1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Targeted
  1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  31 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  8
• GO References
  4

Expression

• Assay Results
  706
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase gadl1

Sequences &
Gene Models

• All Sequences
  48
• RefSeq
  12
• UniProt
  4
• CCDS
  CCDS52954.1

• Ensembl
  ENSMUSG00000056880 (Evidence)
• NCBI Gene
  73748

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000056880	Ensembl Gene Model | MGI Sequence Detail	191297	C57BL/6J
transcript	ENSMUST00000069651	Ensembl | MGI Sequence Detail	3722	Not Applicable
polypeptide	ENSMUSP00000077694	Ensembl | MGI Sequence Detail	522	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000007791 acidic amino acid decarboxylase GADL1
  (term hierarchy)
• PDB
  6ENZ
• EC
  4.1.1.11, 4.1.1.29
• InterPro Domains
  IPR021115 Pyridoxal-phosphate binding site
  IPR002129 Pyridoxal phosphate-dependent decarboxylase
  IPR015424 Pyridoxal phosphate-dependent transferase
  IPR015421 Pyridoxal phosphate-dependent transferase, major domain

Molecular
Reagents

• All nucleic 6

  Genomic 2

  cDNA 4

  
  

  Microarray probesets 2

References

• Summaries
  All 26

  Gene Ontology 4

  Phenotypes 4
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Gadl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87593	Chr9:115737540-115737565 (+)	23,606 bp