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Srrm3 Gene Detail
Summary
  • Symbol
    Srrm3
  • Name
    serine/arginine repetitive matrix 3
  • Synonyms
    2900083I11Rik, SRm300-like, Srrm2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920309
    NCBI Gene: 58212
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135835744-135903626 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.42 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1872 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920309
 protein coding gene Chr5:135835693-135903627 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030191
 protein coding gene Chr5:140391372-140469662 (+)
A/J MGP_AJ_G0030159
 protein coding gene Chr5:134362109-134434063 (+)
AKR/J MGP_AKRJ_G0030092
 protein coding gene Chr5:138711633-138779156 (+)
BALB/cJ MGP_BALBcJ_G0030169
 protein coding gene Chr5:135714463-135786024 (+)
C3H/HeJ MGP_C3HHeJ_G0029885
 protein coding gene Chr5:139297455-139374332 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030622
 protein coding gene Chr5:145627538-145702474 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027845
 protein coding gene Chr5:128662480-128717835 (+)
CAST/EiJ MGP_CASTEiJ_G0029295
 protein coding gene Chr5:138705637-138784747 (+)
CBA/J MGP_CBAJ_G0029855
 protein coding gene Chr5:151286615-151364072 (+)
DBA/2J MGP_DBA2J_G0030006
 protein coding gene Chr5:134257111-134327457 (+)
FVB/NJ MGP_FVBNJ_G0029961
 protein coding gene Chr5:133405020-133476896 (+)
LP/J MGP_LPJ_G0030095
 protein coding gene Chr5:140827707-140899531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029993
 protein coding gene Chr5:154300182-154377512 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030662
 protein coding gene Chr5:138501860-138571231 (+)
PWK/PhJ MGP_PWKPhJ_G0029009
 protein coding gene Chr5:133320191-133390399 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028844
 protein coding gene Chr5:136046350-136116511 (+)
WSB/EiJ MGP_WSBEiJ_G0029368
 protein coding gene Chr5:139226231-139303945 (+)



Homology
more
  • Human Ortholog
    SRRM3, serine/arginine repetitive matrix 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRRM3, serine/arginine repetitive matrix 3
  • Links
    NCBI Gene ID: 222183
    UniProt: A6NNA2

  • Chr Location
    7q11.23; chr7:76201896-76287288 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased survival and body size, impaired coordination, ataxia, and tremors, Purkinje cell degeneration, and longer persistence of the cerebellum external granule cell layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    24
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039860 Ensembl Gene Model | MGI Sequence Detail 67883 C57BL/6J ±  kb
    transcript ENSMUST00000144211 Ensembl | MGI Sequence Detail 3932 Not Applicable  
    polypeptide ENSMUSP00000115695 Ensembl | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030759 serine/arginine repetitive matrix protein 3
      (term hierarchy)
    • InterPro Domains
      IPR013170 mRNA splicing factor Cwf21 domain
      IPR052109 Serine/Arginine Repetitive Matrix Domain-Containing Protein
      IPR047489 Serine/arginine repetitive matrix protein 3, cwf21 domain
      IPR029360 Serine/arginine repetitive matrix protein, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 10
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1931023
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:305017 Nakano Y, et al., Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse. Life Sci Alliance. 2020 Dec;3(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory