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Col14a1 Gene Detail
Summary
  • Symbol
    Col14a1
  • Name
    collagen, type XIV, alpha 1
  • Synonyms
    5730412L22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341272
    NCBI Gene: 12818
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:55171146-55384199 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 21.96 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6737 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341272
 protein coding gene Chr15:55171040-55384199 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021855
 protein coding gene Chr15:54392953-54609388 (+)
A/J MGP_AJ_G0021815
 protein coding gene Chr15:52242771-52453147 (+)
AKR/J MGP_AKRJ_G0021796
 protein coding gene Chr15:53732227-53944111 (+)
BALB/cJ MGP_BALBcJ_G0021822
 protein coding gene Chr15:52460807-52671672 (+)
C3H/HeJ MGP_C3HHeJ_G0021596
 protein coding gene Chr15:53806055-54019537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022261
 protein coding gene Chr15:56500853-56732188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019798
 protein coding gene Chr15:49469509-49678739 (+)
CAST/EiJ MGP_CASTEiJ_G0021113
 protein coding gene Chr15:54397806-54623486 (+)
CBA/J MGP_CBAJ_G0021565
 protein coding gene Chr15:58483182-58711047 (+)
DBA/2J MGP_DBA2J_G0021689
 protein coding gene Chr15:52128926-52338153 (+)
FVB/NJ MGP_FVBNJ_G0021667
 protein coding gene Chr15:51256997-51464975 (+)
LP/J MGP_LPJ_G0021759
 protein coding gene Chr15:54191932-54408763 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021691
 protein coding gene Chr15:63588580-63810132 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022284
 protein coding gene Chr15:54083845-54305385 (+)
PWK/PhJ MGP_PWKPhJ_G0020858
 protein coding gene Chr15:52203268-52418356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020695
 protein coding gene Chr15:53811601-54028192 (+)
WSB/EiJ MGP_WSBEiJ_G0021168
 protein coding gene Chr15:54045386-54261130 (+)



Homology
more
  • Human Ortholog
    COL14A1, collagen type XIV alpha 1 chain
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COL14A1, collagen type XIV alpha 1 chain
  • Synonyms
    UND
  • Links
    NCBI Gene ID: 7373
    neXtProt AC: NX_Q05707
    UniProt: Q05707

  • Chr Location
    8q24.12; chr8:120059780-120373573 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COL14A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal tendon morphology and abnormal biomechanical properties of the skin and tendons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    946
  • Tissues
    93
  • cDNA Data
    61
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022371 Ensembl Gene Model | MGI Sequence Detail 213054 C57BL/6J ±  kb
    transcript ENSMUST00000023053 Ensembl | MGI Sequence Detail 6457 Not Applicable  
    polypeptide ENSMUSP00000023053 Ensembl | MGI Sequence Detail 1797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005698 collagen alpha-1(XIV) chain
      (term hierarchy)
    • InterPro Domains
      IPR008160 Collagen triple helix repeat
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR050525 Extracellular Matrix Assembly and Organization
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR048287 Thrombospondin-like, N-terminal domain
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      Q80X19 6 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 62
      Primer pair 6
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917736, MGI:2146190
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:346374 Ushiki A, et al., Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality. Cell Rep. 2024 Mar 8;43(3):113907
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory