Mrps7 MGI Mouse Gene Detail - MGI:1354367 - mitchondrial ribosomal protein S7

Symbol

Mrps7
Name

mitchondrial ribosomal protein S7
Synonyms

MRP-S7, Rpms7

Feature Type

protein coding gene
IDs

MGI:1354367
NCBI Gene: 50529
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:115494966-115498862 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.90 cM
Mapping Data

1 experiment

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354367	protein coding gene	Chr11:115494751-115498862 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019395	protein coding gene	Chr11:119646803-119650918 (+)
A/J	MGP_AJ_G0019364	protein coding gene	Chr11:114420832-114424993 (+)
AKR/J	MGP_AKRJ_G0019334	protein coding gene	Chr11:117830200-117834334 (+)
BALB/cJ	MGP_BALBcJ_G0019338	protein coding gene	Chr11:114838884-114842983 (+)
C3H/HeJ	MGP_C3HHeJ_G0019144	protein coding gene	Chr11:118190151-118194259 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019788	protein coding gene	Chr11:123297388-123301502 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017411	protein coding gene	Chr11:111444831-111449146 (+)
CAST/EiJ	MGP_CASTEiJ_G0018699	protein coding gene	Chr11:119508942-119513040 (+)
CBA/J	MGP_CBAJ_G0019116	protein coding gene	Chr11:128174712-128178826 (+)
DBA/2J	MGP_DBA2J_G0019227	protein coding gene	Chr11:113852080-113856178 (+)
FVB/NJ	MGP_FVBNJ_G0019219	protein coding gene	Chr11:113341049-113345155 (+)
LP/J	MGP_LPJ_G0019297	protein coding gene	Chr11:120031040-120035156 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019252	protein coding gene	Chr11:127313440-127317539 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019826	protein coding gene	Chr11:118489236-118493339 (+)
PWK/PhJ	MGP_PWKPhJ_G0018463	protein coding gene	Chr11:115142483-115146342 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018256	protein coding gene	Chr11:118238149-118242333 (+)
WSB/EiJ	MGP_WSBEiJ_G0018751	protein coding gene	Chr11:118453368-118457475 (+)

Human Ortholog

MRPS7, mitochondrial ribosomal protein S7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPS7, mitochondrial ribosomal protein S7
Synonyms

bMRP27a, COXPD34, MRP-S, MRP-S7, RPMS7, RP-S7, S7mt, uS7m
Links

HGNC:14499

NCBI Gene ID: 51081

neXtProt AC: NX_Q9Y2R9

UniProt: Q9Y2R9
Chr Location

17q25.1; chr17:75261674-75266376 (+) GRCh38

MGI Vertebrate Homology

Mrps7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPS7
Gene Tree

Mrps7

Diseases

1 with human MRPS7 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 34 IDs combined oxidative phosphorylation deficiency 34 DOID:0111497 OMIM:617872 ORDO:457223

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

10
Gene trapped

9
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

13
cDNA Data

81
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrps7

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS25642.1

Ensembl

ENSMUSG00000046756 (Evidence)
NCBI Gene

50529

			Length	Strain/Species	Flank
genomic	50529	NCBI Gene Model \| MGI Sequence Detail	3897	C57BL/6J	± kb
transcript	NM_025305	RefSeq \| MGI Sequence Detail	1747	C57BL/6
polypeptide	Q80X85	UniProt \| EBI \| MGI Sequence Detail	242	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010645 small ribosomal subunit protein uS7m

(term hierarchy)
PDB

7PNT, 7PNU, 7PNV, 7PNW
InterPro Domains

IPR000235 Small ribosomal subunit protein uS7

IPR023798 Small ribosomal subunit protein uS7 domain

IPR036823 Small ribosomal subunit protein uS7 domain superfamily

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All nucleic 82

cDNA 81

Primer pair 1

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 6
Earliest

J:58929 Cavdar Koc E, et al., Identification of a mammalian mitochondrial homolog of ribosomal protein S7. Biochem Biophys Res Commun. 1999 Dec 9;266(1):141-6
Latest

J:297050 Cheong A, et al., Expression analysis of mammalian mitochondrial ribosomal protein genes. Gene Expr Patterns. 2020 Sep 25;38:119147

TSS for Mrps7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105886	Chr11:115494746-115494795 (+)	-195 bp
Tssr105887	Chr11:115494801-115494820 (+)	-155 bp
Tssr105888	Chr11:115494956-115494990 (+)	7 bp
Tssr105889	Chr11:115494995-115495006 (+)	35 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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