Cyth4 MGI Mouse Gene Detail - MGI:2441702

Symbol

Cyth4
Name

cytohesin 4
Synonyms

2510004M07Rik, 5830469K17Rik, Pscd4

Feature Type

protein coding gene
IDs

MGI:2441702
NCBI Gene: 72318
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr15:78481247-78506219 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.59 cM
Mapping Data

2 experiments

SNPs within 2kb

833 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441702	protein coding gene	Chr15:78481247-78506219 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022049	protein coding gene	Chr15:78805095-78830028 (+)
A/J	MGP_AJ_G0022010	protein coding gene	Chr15:76099194-76124325 (+)
AKR/J	MGP_AKRJ_G0021985	protein coding gene	Chr15:78206894-78231839 (+)
BALB/cJ	MGP_BALBcJ_G0022016	protein coding gene	Chr15:76071498-76096451 (+)
C3H/HeJ	MGP_C3HHeJ_G0021787	protein coding gene	Chr15:78207687-78233537 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022459	protein coding gene	Chr15:81911304-81936279 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019989	protein coding gene	Chr15:72596276-72621008 (+)
CAST/EiJ	MGP_CASTEiJ_G0021308	protein coding gene	Chr15:78892444-78919746 (+)
CBA/J	MGP_CBAJ_G0021752	protein coding gene	Chr15:84439363-84464358 (+)
DBA/2J	MGP_DBA2J_G0021881	protein coding gene	Chr15:75583245-75608242 (+)
FVB/NJ	MGP_FVBNJ_G0021859	protein coding gene	Chr15:74586011-74611538 (+)
LP/J	MGP_LPJ_G0021949	protein coding gene	Chr15:79011969-79037052 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021879	protein coding gene	Chr15:89620502-89645464 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022473	protein coding gene	Chr15:78233812-78258755 (+)
PWK/PhJ	MGP_PWKPhJ_G0021050	protein coding gene	Chr15:75577264-75603138 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020887	protein coding gene	Chr15:78015254-78042198 (+)
WSB/EiJ	MGP_WSBEiJ_G0021360	protein coding gene	Chr15:78592971-78617943 (+)

Human Ortholog

CYTH4, cytohesin 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYTH4, cytohesin 4
Synonyms

CYT4, cytohesin-4, DJ63G5.1, PSCD4
Links

HGNC:9505

NCBI Gene ID: 27128

neXtProt AC: NX_Q9UIA0

UniProt: Q9UIA0
Chr Location

22q13.1; chr22:37282027-37315341 (+) GRCh38

MGI Vertebrate Homology

Cyth4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CYTH4
Gene Tree

Cyth4

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Cyth4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

39
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyth4

ZFIN cyth4a, cyth4b

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All Sequences

85
RefSeq

12
UniProt

14
CCDS

CCDS27620.1

Ensembl

ENSMUSG00000018008 (Evidence)
NCBI Gene

72318

			Length	Strain/Species	Flank
genomic	72318	NCBI Gene Model \| MGI Sequence Detail	24973	C57BL/6J	± kb
transcript	NM_028195	RefSeq \| MGI Sequence Detail	2791	C57BL/6
polypeptide	Q80YW0	UniProt \| EBI \| MGI Sequence Detail	393	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000006156 cytohesin-4

(term hierarchy)
InterPro Domains

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR023394 Sec7, C-terminal domain superfamily

IPR000904 Sec7 domain

IPR035999 Sec7 domain superfamily

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All nucleic 40

cDNA 39

Primer pair 1

Microarray probesets 3

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MGI:1919568, MGI:2146026

Summaries

All 51

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 24
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:272623 Kinoshita-Kawada M, et al., A crucial role for Arf6 in the response of commissural axons to Slit. Development. 2019 Feb 4;146(3):dev172106

TSS for Cyth4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131970	Chr15:78481312-78481321 (+)	70 bp
Tssr131971	Chr15:78481333-78481352 (+)	96 bp
Tssr131972	Chr15:78482259-78482317 (+)	1,041 bp
Tssr131973	Chr15:78486912-78486933 (+)	5,676 bp
Tssr131974	Chr15:78486970-78486987 (+)	5,732 bp
Tssr131975	Chr15:78492315-78492328 (+)	11,075 bp
Tssr131976	Chr15:78494014-78494035 (+)	12,778 bp
Tssr4648	Chr15:78495614-78495625 (+)	14,373 bp
Tssr4649	Chr15:78495627-78495707 (+)	14,420 bp
Tssr131977	Chr15:78499940-78499949 (+)	18,698 bp
Tssr131978	Chr15:78499961-78499980 (+)	18,724 bp
Tssr131979	Chr15:78500022-78500037 (+)	18,783 bp
Tssr131980	Chr15:78500039-78500050 (+)	18,798 bp
Tssr131981	Chr15:78500126-78500152 (+)	18,892 bp
Tssr131982	Chr15:78500174-78500183 (+)	18,932 bp
Tssr131983	Chr15:78500495-78500683 (+)	19,342 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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