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Siglecg Gene Detail
Summary
  • Symbol
    Siglecg
  • Name
    sialic acid binding Ig-like lectin G
  • Synonyms
    A630096C01Rik, mSiglec-G
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443630
    NCBI Gene: 243958
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43057623-43067773 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    404 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443630
 protein coding gene Chr7:43057623-43067782 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032119
 protein coding gene Chr7:43417871-43431656 (+)
A/J MGP_AJ_G0032104
 protein coding gene Chr7:42534928-42545303 (+)
AKR/J MGP_AKRJ_G0032034
 protein coding gene Chr7:43903672-43913613 (+)
BALB/cJ MGP_BALBcJ_G0032109
 protein coding gene Chr7:42648156-42660087 (+)
C3H/HeJ MGP_C3HHeJ_G0031825
 protein coding gene Chr7:44401372-44413449 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032593
 protein coding gene Chr7:45608015-45626045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029616
 protein coding gene Chr7:44656817-44666676 (+)
CAST/EiJ MGP_CASTEiJ_G0031155
 protein coding gene Chr7:35579740-35589167 (+)
CBA/J MGP_CBAJ_G0031794
 protein coding gene Chr7:47050918-47067744 (+)
DBA/2J MGP_DBA2J_G0031943
 protein coding gene Chr7:42334970-42345082 (+)
FVB/NJ MGP_FVBNJ_G0031904
 protein coding gene Chr7:42053637-42064228 (+)
LP/J MGP_LPJ_G0032022
 protein coding gene Chr7:44150952-44171149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031940
 protein coding gene Chr7:46005590-46019666 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032613
 protein coding gene Chr7:43024434-43044005 (+)
PWK/PhJ MGP_PWKPhJ_G0030876
 protein coding gene Chr7:35769829-35784385 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030715
 protein coding gene Chr7:31083888-31093963 (+)
WSB/EiJ MGP_WSBEiJ_G0031269
 protein coding gene Chr7:43573671-43586889 (+)



Homology
more
  • Human Ortholog
    SIGLEC10, sialic acid binding Ig like lectin 10
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC10, sialic acid binding Ig like lectin 10
  • Synonyms
    PRO940, SIGLEC-10, SLG2
  • Links
    NCBI Gene ID: 89790
    neXtProt AC: NX_Q96LC7
    UniProt: Q96LC7

  • Chr Location
    19q13.41; chr19:51410020-51417803 (-)  GRCh38
  • Human Ortholog
    SIGLEC11, sialic acid binding Ig like lectin 11
  • Links
    NCBI Gene ID: 114132
    neXtProt AC: NX_Q96RL6
    UniProt: Q96RL6

  • Chr Location
    19q13.33; chr19:49948985-49961172 (-)  GRCh38
  • Human Ortholog
    SIGLEC16, sialic acid binding Ig like lectin 16 (gene/pseudogene)
  • Synonyms
    Siglec-P16, SIGLECP16
  • Links
    NCBI Gene ID: 400709
    UniProt: A6NMB1

  • Chr Location
    19q13.33
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased B-1 cell numbers, increased IgM levels and IgM-producing plasma cells, and produce more IgM autoantibodies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243958 NCBI Gene Model | MGI Sequence Detail 10151 C57BL/6J ±  kb
    transcript NR_175813 RefSeq | MGI Sequence Detail 2604 C57BL/6  
    polypeptide Q80ZE3 UniProt | EBI | MGI Sequence Detail 688 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 30
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345011 Korn MA, et al., Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus. Front Immunol. 2023;14:1095830
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory