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Adgrb3 Gene Detail
Summary
  • Symbol
    Adgrb3
  • Name
    adhesion G protein-coupled receptor B3
  • Synonyms
    A830096D10Rik, Bai3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441837
    NCBI Gene: 210933
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:25106557-25868788 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 10.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21415 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441837
 protein coding gene Chr1:25106557-25869338 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015892
 protein coding gene Chr1:22943438-23726800 (-)
A/J MGP_AJ_G0015873
 protein coding gene Chr1:22469562-23230930 (-)
AKR/J MGP_AKRJ_G0015830
 protein coding gene Chr1:22738630-23486033 (-)
BALB/cJ MGP_BALBcJ_G0015829
 protein coding gene Chr1:22227251-22997639 (-)
C3H/HeJ MGP_C3HHeJ_G0015663
 protein coding gene Chr1:22729701-23512384 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016283
 protein coding gene Chr1:23985124-24815525 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014002
 protein coding gene Chr1:20480786-21204718 (-)
CAST/EiJ MGP_CASTEiJ_G0015242
 protein coding gene Chr1:22817337-23582078 (-)
CBA/J MGP_CBAJ_G0015635
 protein coding gene Chr1:24578434-25417166 (-)
DBA/2J MGP_DBA2J_G0015734
 protein coding gene Chr1:21950112-22703625 (-)
FVB/NJ MGP_FVBNJ_G0015738
 protein coding gene Chr1:21687628-22435487 (-)
LP/J MGP_LPJ_G0015806
 protein coding gene Chr1:23147453-23944170 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015758
 protein coding gene Chr1:25585511-26496591 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016330
 protein coding gene Chr1:22615310-23376680 (-)
PWK/PhJ MGP_PWKPhJ_G0015025
 protein coding gene Chr1:21684380-22435271 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014806
 protein coding gene Chr1:22718941-23487264 (-)
WSB/EiJ MGP_WSBEiJ_G0015305
 protein coding gene Chr1:22571157-23365961 (-)



Homology
more
  • Human Ortholog
    ADGRB3, adhesion G protein-coupled receptor B3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRB3, adhesion G protein-coupled receptor B3
  • Synonyms
    BAI3
  • Links
    NCBI Gene ID: 577
    neXtProt AC: NX_O60242
    UniProt: O60242

  • Chr Location
    6q12-q13; chr6:68635282-69390571 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in Purkinje cells exhibit impaired motor learning with alterned climbing fiber electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    30
  • cDNA Data
    35
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033569 Ensembl Gene Model | MGI Sequence Detail 762232 C57BL/6J ±  kb
transcript ENSMUST00000041838 Ensembl | MGI Sequence Detail 5059 Not Applicable  
polypeptide ENSMUSP00000035612 Ensembl | MGI Sequence Detail 1522 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004631 adhesion G protein-coupled receptor B3
    (term hierarchy)
  • InterPro Domains
    IPR043838 Adhesion G protein-coupled receptor B, N-terminal domain
    IPR052065 Complement and asymmetry regulator
    IPR032471 GAIN domain, N-terminal
    IPR046338 GAIN domain superfamily
    IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
    IPR017981 GPCR, family 2-like, 7TM
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
    IPR000203 GPS motif
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
  • GlyGen
    Q80ZF8 15 sites, 7 N-linked glycans (6 sites), 1 O-linked glycan (2 sites)
Molecular
Reagents
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  • All nucleic 39
    cDNA 36
    Primer pair 3

    Microarray probesets 1
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:77162 Kee HJ, et al., Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory