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Disc1 Gene Detail
Summary
  • Symbol
    Disc1
  • Name
    disrupted in schizophrenia 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447658
    NCBI Gene: 244667
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125780934-125988597 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 73.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447658
 protein coding gene Chr8:125773928-125991882 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034285
 protein coding gene Chr8:128787506-129017374 (+)
A/J MGP_AJ_G0034265
 protein coding gene Chr8:123432453-123641608 (+)
AKR/J MGP_AKRJ_G0034192
 protein coding gene Chr8:127003533-127224652 (+)
BALB/cJ MGP_BALBcJ_G0034258
 protein coding gene Chr8:123615921-123827273 (+)
C3H/HeJ MGP_C3HHeJ_G0033969
 protein coding gene Chr8:127647563-127865924 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034778
 protein coding gene Chr8:133086905-133311692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031719
 protein coding gene Chr8:116189145-116400535 (+)
CAST/EiJ MGP_CASTEiJ_G0033296
 protein coding gene Chr8:127776497-127997443 (+)
CBA/J MGP_CBAJ_G0033942
 protein coding gene Chr8:137967083-138211376 (+)
DBA/2J MGP_DBA2J_G0034098
 protein coding gene Chr8:122603479-122815332 (+)
FVB/NJ MGP_FVBNJ_G0034042
 protein coding gene Chr8:121771495-121997142 (+)
LP/J MGP_LPJ_G0034187
 protein coding gene Chr8:128943394-129171845 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034089
 protein coding gene Chr8:140033003-140253406 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034797
 protein coding gene Chr8:127252331-127471330 (+)
PWK/PhJ MGP_PWKPhJ_G0032998
 protein coding gene Chr8:122352778-122569482 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032837
 protein coding gene Chr8:125881198-126087385 (+)
WSB/EiJ MGP_WSBEiJ_G0033413
 protein coding gene Chr8:127963475-128186274 (+)



Homology
more
  • Human Ortholog
    DISC1, DISC1 scaffold protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DISC1, DISC1 scaffold protein
  • Synonyms
    C1orf136, SCZD9
  • Links
    NCBI Gene ID: 27185
    neXtProt AC: NX_Q9NRI5
    UniProt: Q9NRI5

  • Chr Location
    1q42.2; chr1:231626790-232041272 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Disc1 mouse models; 8 with human DISC1 associations

Human Disease Mouse Models
      
IDs
 View 7 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 9 alleles in 10 genetic backgrounds
    12 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show altered anxiety, synaptic depression, LTP, impulsivity, social investigation, hyperactivity and prepulse inhibition. Homozygotes for a spontaneous allele show altered working memory. Different ENU mutations cause distinct depression and schizophrenia-like profiles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    965
  • Tissues
    82
  • cDNA Data
    7
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043051 Ensembl Gene Model | MGI Sequence Detail 207664 C57BL/6J ±  kb
    transcript ENSMUST00000098311 Ensembl | MGI Sequence Detail 2597 Not Applicable  
    polypeptide ENSMUSP00000095914 Ensembl | MGI Sequence Detail 852 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 3
      cDNA 7

      Microarray probesets 1
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 19
      Diseases 6
      Gene Ontology 22
      Phenotypes 76
    • Earliest
      J:80804 Ma L, et al., Cloning and Characterization of Disc1, the Mouse Ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 2002 Dec;80(6):662-72
    • Latest
      J:352329 Wu Q, et al., Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia. Transl Psychiatry. 2024 Feb 6;14(1):79
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory