Prr5 MGI Mouse Gene Detail - MGI:1924714

Symbol

Prr5
Name

proline rich 5 (renal)
Synonyms

C030017C09Rik, Protor-1

Feature Type

protein coding gene
IDs

MGI:1924714
NCBI Gene: 109270
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:84553821-84587874 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.95 cM, cytoband E
Mapping Data

6 experiments

SNPs within 2kb

937 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924714	protein coding gene	Chr15:84547407-84590610 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022180	protein coding gene	Chr15:85493742-85518951 (+)
A/J	MGP_AJ_G0022139	protein coding gene	Chr15:82329884-82352654 (+)
AKR/J	MGP_AKRJ_G0022114	protein coding gene	Chr15:84732664-84754664 (+)
BALB/cJ	MGP_BALBcJ_G0022145	protein coding gene	Chr15:82461450-82487359 (+)
C3H/HeJ	MGP_C3HHeJ_G0021915	protein coding gene	Chr15:84702405-84724540 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022590	protein coding gene	Chr15:88742857-88768080 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020115	protein coding gene	Chr15:78681141-78704177 (+)
CAST/EiJ	MGP_CASTEiJ_G0021437	protein coding gene	Chr15:85492741-85518283 (+)
CBA/J	MGP_CBAJ_G0021882	protein coding gene	Chr15:91626512-91652914 (+)
DBA/2J	MGP_DBA2J_G0022009	protein coding gene	Chr15:81803899-81829254 (+)
FVB/NJ	MGP_FVBNJ_G0021988	protein coding gene	Chr15:80860319-80882353 (+)
LP/J	MGP_LPJ_G0022080	protein coding gene	Chr15:85644541-85666558 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022008	protein coding gene	Chr15:96412670-96440398 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022605	protein coding gene	Chr15:84746793-84768953 (+)
PWK/PhJ	MGP_PWKPhJ_G0021178	protein coding gene	Chr15:81811100-81833118 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021012	protein coding gene	Chr15:84462954-84484887 (+)
WSB/EiJ	MGP_WSBEiJ_G0021486	protein coding gene	Chr15:85245911-85272356 (+)

Human Ortholog

PRR5, proline rich 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRR5, proline rich 5
Synonyms

FLJ20185k, PP610, PROTOR-1, PROTOR1
Links

HGNC:31682

NCBI Gene ID: 55615

neXtProt AC: NX_P85299

UniProt: P85299
Chr Location

22q13.31; chr22:44668547-44737681 (+) GRCh38

MGI Vertebrate Homology

Prr5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRR5
Gene Tree

Prr5

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

13
Radiation induced

2
Genomic Mutations

3 involving Prr5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prr5

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All Sequences

53
RefSeq

10
UniProt

1
CCDS

CCDS27711.1, CCDS84185.1

Ensembl

ENSMUSG00000036106 (Evidence)
NCBI Gene

109270

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036106	Ensembl Gene Model \| MGI Sequence Detail	34054	C57BL/6J	± kb
transcript	ENSMUST00000065499	Ensembl \| MGI Sequence Detail	1830	Not Applicable
polypeptide	ENSMUSP00000066396	Ensembl \| MGI Sequence Detail	387	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013271 protor-1

(term hierarchy)
InterPro Domains

IPR016159 Cullin repeat-like-containing domain superfamily

IPR013745 TORC2 component Bit61/PRR5

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All nucleic 14

cDNA 12

Primer pair 2

Microarray probesets 4

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MGI:2146155, MGI:2146287

Summaries

All 55

Diseases 1

Gene Ontology 7

Phenotypes 27
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prr5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132470	Chr15:84553766-84553810 (+)	-33 bp
Tssr132471	Chr15:84553846-84553848 (+)	26 bp
Tssr132472	Chr15:84557063-84557067 (+)	3,244 bp
Tssr132473	Chr15:84565175-84565245 (+)	11,389 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24