Zfp418 MGI Mouse Gene Detail - MGI:2444763

Symbol

Zfp418
Name

zinc finger protein 418
Synonyms

A230102I05Rik

Feature Type

protein coding gene
IDs

MGI:2444763
NCBI Gene: 232854
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:7174352-7186559 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 4.16 cM
Mapping Data

1 experiment

SNPs within 2kb

347 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444763	protein coding gene	Chr7:7174329-7186561 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031618	protein coding gene	Chr7:4274749-4286981 (+)
A/J	MGP_AJ_G0031593	protein coding gene	Chr7:4142957-4155177 (+)
AKR/J	MGP_AKRJ_G0031519	protein coding gene	Chr7:4435386-4447642 (+)
BALB/cJ	MGP_BALBcJ_G0031601	protein coding gene	Chr7:4249805-4262037 (+)
C3H/HeJ	MGP_C3HHeJ_G0031321	protein coding gene	Chr7:4273226-4285458 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032063	protein coding gene	Chr7:4508315-4520545 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029175	protein coding gene	Chr7:3786659-3799127 (+)
CAST/EiJ	MGP_CASTEiJ_G0030683	protein coding gene	Chr7:4160143-4172354 (+)
CBA/J	MGP_CBAJ_G0031278	protein coding gene	Chr7:4672742-4685092 (+)
DBA/2J	MGP_DBA2J_G0031436	protein coding gene	Chr7:4229906-4242138 (+)
FVB/NJ	MGP_FVBNJ_G0031390	protein coding gene	Chr7:4161181-4173421 (+)
LP/J	MGP_LPJ_G0031522	protein coding gene	Chr7:4398262-4410476 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031429	protein coding gene	Chr7:4667633-4680778 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032092	protein coding gene	Chr7:4200970-4213599 (+)
PWK/PhJ	MGP_PWKPhJ_G0030410	protein coding gene	Chr7:4353003-4365221 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030237	protein coding gene	Chr7:3720777-3735283 (+)
WSB/EiJ	MGP_WSBEiJ_G0030777	protein coding gene	Chr7:4351256-4363452 (+)

Human Ortholog

ZNF416, zinc finger protein 416

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF416, zinc finger protein 416
Links

HGNC:20645

NCBI Gene ID: 55659

neXtProt AC: NX_Q9BWM5

UniProt: Q9BWM5
Chr Location

19q13.43; chr19:57571566-57578911 (-) GRCh38

MGI Vertebrate Homology

Zfp418 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZNF416
Gene Tree

Zfp418

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene exacerbates aortic banding-induced cardiac hypertrophy and fibrosis.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS39756.1

Ensembl

ENSMUSG00000034538 (Evidence)
NCBI Gene

232854

			Length	Strain/Species	Flank
genomic	232854	NCBI Gene Model \| MGI Sequence Detail	12208	C57BL/6J	± kb
transcript	NM_146179	RefSeq \| MGI Sequence Detail	2700	C57BL/6
polypeptide	Q8BFS8	UniProt \| EBI \| MGI Sequence Detail	652	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR036051 KRAB domain superfamily

IPR001909 Krueppel-associated box

IPR050169 Krueppel C2H2-type zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 14

cDNA 14

Microarray probesets 2

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 4
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:338229 Singh SR, et al., A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway. Autophagy. 2021 Oct;17(10):3124-3139

TSS for Zfp418:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64462	Chr7:7174345-7174372 (+)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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