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Lpp Gene Detail
Summary
  • Symbol
    Lpp
  • Name
    LIM domain containing preferred translocation partner in lipoma
  • Synonyms
    9430020K16Rik, B130055L10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441849
    NCBI Gene: 210126
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:24212257-24811328 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 16.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15726 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441849
 protein coding gene Chr16:24212100-24811328 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022689
 protein coding gene Chr16:22024286-22659671 (+)
A/J MGP_AJ_G0022651
 protein coding gene Chr16:20986026-21590855 (+)
AKR/J MGP_AKRJ_G0022625
 protein coding gene Chr16:21861469-22472376 (+)
BALB/cJ MGP_BALBcJ_G0022656
 protein coding gene Chr16:21192273-21791148 (+)
C3H/HeJ MGP_C3HHeJ_G0022420
 protein coding gene Chr16:21977903-22583550 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023105
 protein coding gene Chr16:22565950-23184938 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020623
 protein coding gene Chr16:21610586-22209546 (+)
CAST/EiJ MGP_CASTEiJ_G0021949
 protein coding gene Chr16:22006240-22626521 (+)
CBA/J MGP_CBAJ_G0022391
 protein coding gene Chr16:23499760-24136906 (+)
DBA/2J MGP_DBA2J_G0022523
 protein coding gene Chr16:20944753-21542744 (+)
FVB/NJ MGP_FVBNJ_G0022499
 protein coding gene Chr16:20937818-21539495 (+)
LP/J MGP_LPJ_G0022591
 protein coding gene Chr16:21821886-22439928 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022518
 protein coding gene Chr16:22937604-23569770 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023117
 protein coding gene Chr16:21819984-22436793 (+)
PWK/PhJ MGP_PWKPhJ_G0021688
 protein coding gene Chr16:21213029-21817821 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021519
 protein coding gene Chr16:21556618-22187316 (+)
WSB/EiJ MGP_WSBEiJ_G0021993
 protein coding gene Chr16:21777005-22396836 (+)



Homology
more
  • Human Ortholog
    LPP, LIM domain containing preferred translocation partner in lipoma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPP, LIM domain containing preferred translocation partner in lipoma
  • Links
    NCBI Gene ID: 4026
    neXtProt AC: NX_Q93052
    UniProt: Q93052

  • Chr Location
    3q27.3-q28; chr3:188153021-188890671 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LPP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene disruption results in fertility problems involving females but not males. Migration and survival of MEFs are also abnormal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    927
  • Tissues
    107
  • cDNA Data
    33
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033306 Ensembl Gene Model | MGI Sequence Detail 599072 C57BL/6J ±  kb
    transcript ENSMUST00000078988 Ensembl | MGI Sequence Detail 3894 Not Applicable  
    polypeptide ENSMUSP00000078005 Ensembl | MGI Sequence Detail 613 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 39
      Primer pair 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2146367, MGI:2146570, MGI:2146704
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory