B3galnt2 MGI Mouse Gene Detail - MGI:2145517 - UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2

Symbol

B3galnt2
Name

UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
Synonyms

A930105D20Rik, D230016N13Rik

Feature Type

protein coding gene
IDs

MGI:2145517
NCBI Gene: 97884
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:14129059-14173688 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 5.29 cM
Mapping Data

2 experiments

SNPs within 2kb

985 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145517	protein coding gene	Chr13:14129054-14173688 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020238	protein coding gene	Chr13:10923942-10967458 (+)
A/J	MGP_AJ_G0020196	protein coding gene	Chr13:10843750-10895832 (+)
AKR/J	MGP_AKRJ_G0020170	protein coding gene	Chr13:10961012-11008076 (+)
BALB/cJ	MGP_BALBcJ_G0020182	protein coding gene	Chr13:10830045-10875339 (+)
C3H/HeJ	MGP_C3HHeJ_G0019986	protein coding gene	Chr13:11119083-11163764 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020626	protein coding gene	Chr13:11496641-11540579 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018232	protein coding gene	Chr13:9581740-9624906 (+)
CAST/EiJ	MGP_CASTEiJ_G0019520	protein coding gene	Chr13:10781954-10830565 (+)
CBA/J	MGP_CBAJ_G0019950	protein coding gene	Chr13:11847357-11896774 (+)
DBA/2J	MGP_DBA2J_G0020069	protein coding gene	Chr13:10499837-10546136 (+)
FVB/NJ	MGP_FVBNJ_G0020050	protein coding gene	Chr13:10260291-10304588 (+)
LP/J	MGP_LPJ_G0020139	protein coding gene	Chr13:11103371-11151464 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020087	protein coding gene	Chr13:11951458-11997973 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020653	protein coding gene	Chr13:10767079-10817643 (+)
PWK/PhJ	MGP_PWKPhJ_G0019283	protein coding gene	Chr13:10575345-10619288 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019091	protein coding gene	Chr13:9938863-9983186 (+)
WSB/EiJ	MGP_WSBEiJ_G0019581	protein coding gene	Chr13:10793079-10839091 (+)

Human Ortholog

B3GALNT2, beta-1,3-N-acetylgalactosaminyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

B3GALNT2, beta-1,3-N-acetylgalactosaminyltransferase 2
Synonyms

B3GalNAc-T2, MDDGA11
Links

HGNC:28596

NCBI Gene ID: 148789

neXtProt AC: NX_Q8NCR0

UniProt: Q8NCR0
Chr Location

1q42.3; chr1:235439796-235504452 (-) GRCh38

MGI Vertebrate Homology

B3galnt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: B3GALNT2
Gene Tree

B3galnt2

Diseases

1 with human B3GALNT2 associations

				Human Disease	Mouse Models
				congenital muscular dystrophy-dystroglycanopathy type A11 IDs congenital muscular dystrophy-dystroglycanopathy type A11 DOID:0111230 OMIM:615181

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Endonuclease-mediated

3
Gene trapped

43
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

69 strains or lines available

less

All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

1
cDNA Data

98
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase b3galnt2

ZFIN b3galnt2

less

All Sequences

74
RefSeq

10
UniProt

6
CCDS

CCDS26246.1

Ensembl

ENSMUSG00000039242 (Evidence)
NCBI Gene

97884

			Length	Strain/Species	Flank
genomic	97884	NCBI Gene Model \| MGI Sequence Detail	44630	C57BL/6J	± kb
transcript	NM_178640	RefSeq \| MGI Sequence Detail	3716	C57BL/6
polypeptide	Q8BG28	UniProt \| EBI \| MGI Sequence Detail	504	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000004582 UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

(term hierarchy)
EC

2.4.1.-, 2.4.1.313
InterPro Domains

IPR002659 Glycosyl transferase, family 31
GlyGen

Q8BG28 2 sites

less

All nucleic 98

cDNA 98

Microarray probesets 5

less

MGI:2441846

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for B3galnt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118385	Chr13:14129124-14129140 (+)	73 bp
Tssr118386	Chr13:14129199-14129276 (+)	179 bp
Tssr118387	Chr13:14129279-14129290 (+)	226 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24