Efr3a MGI Mouse Gene Detail - MGI:1923990

Symbol

Efr3a
Name

EFR3 homolog A
Synonyms

A130089M23Rik, C920006C10Rik, D030063F01Rik, mKIAA0143

Feature Type

protein coding gene
IDs

MGI:1923990
NCBI Gene: 76740
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:65658883-65745665 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 29.12 cM
Mapping Data

2 experiments

SNPs within 2kb

2233 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923990	protein coding gene	Chr15:65658852-65745665 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021900	protein coding gene	Chr15:65287415-65370912 (+)
A/J	MGP_AJ_G0021859	protein coding gene	Chr15:62790178-62874533 (+)
AKR/J	MGP_AKRJ_G0021841	protein coding gene	Chr15:64546934-64634285 (+)
BALB/cJ	MGP_BALBcJ_G0021866	protein coding gene	Chr15:62975721-63063290 (+)
C3H/HeJ	MGP_C3HHeJ_G0021639	protein coding gene	Chr15:64656022-64744458 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022305	protein coding gene	Chr15:67799284-67895427 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019842	protein coding gene	Chr15:59609703-59695827 (+)
CAST/EiJ	MGP_CASTEiJ_G0021158	protein coding gene	Chr15:65320735-65400871 (+)
CBA/J	MGP_CBAJ_G0021605	protein coding gene	Chr15:70110411-70194132 (+)
DBA/2J	MGP_DBA2J_G0021730	protein coding gene	Chr15:62590697-62676855 (+)
FVB/NJ	MGP_FVBNJ_G0021712	protein coding gene	Chr15:61632882-61716647 (+)
LP/J	MGP_LPJ_G0021802	protein coding gene	Chr15:65157893-65256197 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021735	protein coding gene	Chr15:75181972-75276697 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022327	protein coding gene	Chr15:64923999-65007758 (+)
PWK/PhJ	MGP_PWKPhJ_G0020899	protein coding gene	Chr15:62678065-62763431 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020740	protein coding gene	Chr15:64774334-64861761 (+)
WSB/EiJ	MGP_WSBEiJ_G0021210	protein coding gene	Chr15:64894643-64984843 (+)

Human Ortholog

EFR3A, EFR3 homolog A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EFR3A, EFR3 homolog A
Links

HGNC:28970

NCBI Gene ID: 23167

neXtProt AC: NX_Q14156

UniProt: Q14156
Chr Location

8q24.22; chr8:131904093-132013642 (+) GRCh38

MGI Vertebrate Homology

Efr3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EFR3A
Gene Tree

Efr3a

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

3
Endonuclease-mediated

3
Gene trapped

14
Radiation induced

2
Targeted

5
Genomic Mutations

5 involving Efr3a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a conditional allele activated in the nervous system exhibit decreased neuron apoptosis in the dentate gyrus resulting in increased adult hippocampal neurogenesis.

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

29
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase efr3a

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All Sequences

80
RefSeq

8
UniProt

6
CCDS

CCDS27507.1

Ensembl

ENSMUSG00000015002 (Evidence)
NCBI Gene

76740

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015002	Ensembl Gene Model \| MGI Sequence Detail	86783	C57BL/6J	± kb
transcript	ENSMUST00000211878	Ensembl \| MGI Sequence Detail	2541	Not Applicable
polypeptide	ENSMUSP00000148418	Ensembl \| MGI Sequence Detail	846	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006924 protein EFR3 homolog A

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR051851 EFR3 Homologs

IPR049152 EFR3-like, armadillo repeat
GlyGen

Q8BG67 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 18

Microarray probesets 7

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MGI:2146257, MGI:2146271, MGI:2443702

Summaries

All 68

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 37
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Efr3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131458	Chr15:65658872-65658939 (+)	23 bp
Tssr131459	Chr15:65658949-65658966 (+)	75 bp
Tssr131460	Chr15:65676854-65676861 (+)	17,975 bp
Tssr131461	Chr15:65682028-65682035 (+)	23,149 bp
Tssr131462	Chr15:65682066-65682077 (+)	23,189 bp
Tssr131463	Chr15:65737512-65737547 (+)	78,647 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24