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Lrrtm2 Gene Detail
Summary
  • Symbol
    Lrrtm2
  • Name
    leucine rich repeat transmembrane neuronal 2
  • Synonyms
    C630011A14Rik, mKIAA0416
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389174
    NCBI Gene: 107065
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35342056-35348077 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2389174
 protein coding gene Chr18:35342056-35348077 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024257
 protein coding gene Chr18:33489597-33495605 (-)
A/J MGP_AJ_G0024223
 protein coding gene Chr18:32330850-32336863 (-)
AKR/J MGP_AKRJ_G0024191
 protein coding gene Chr18:33257875-33263889 (-)
BALB/cJ MGP_BALBcJ_G0024223
 protein coding gene Chr18:32394754-32400767 (-)
C3H/HeJ MGP_C3HHeJ_G0023990
 protein coding gene Chr18:33287900-33293914 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024665
 protein coding gene Chr18:34729458-34735553 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022105
 protein coding gene Chr18:32468780-32474789 (-)
CAST/EiJ MGP_CASTEiJ_G0023465
 protein coding gene Chr18:33269741-33275749 (-)
CBA/J MGP_CBAJ_G0023958
 protein coding gene Chr18:35711908-35717921 (-)
DBA/2J MGP_DBA2J_G0024090
 protein coding gene Chr18:31987027-31993585 (-)
FVB/NJ MGP_FVBNJ_G0024057
 protein coding gene Chr18:31672237-31678250 (-)
LP/J MGP_LPJ_G0024172
 protein coding gene Chr18:33557938-33563965 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024085
 protein coding gene Chr18:36950483-36957416 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024713
 protein coding gene Chr18:33093894-33099907 (-)
PWK/PhJ MGP_PWKPhJ_G0023209
 protein coding gene Chr18:32208076-32214106 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023017
 protein coding gene Chr18:33358950-33364960 (-)
WSB/EiJ MGP_WSBEiJ_G0023528
 protein coding gene Chr18:33021053-33027132 (-)



Homology
more
  • Human Ortholog
    LRRTM2, leucine rich repeat transmembrane neuronal 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRTM2, leucine rich repeat transmembrane neuronal 2
  • Links
    NCBI Gene ID: 26045
    neXtProt AC: NX_O43300
    UniProt: O43300

  • Chr Location
    5q31.2; chr5:138868921-138875368 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
When conditionally deleted in addition to Lrrtm1, mice homozygous for a conditional allele exhibit impaired basal AMPA receptor transmission and LTP.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107065 NCBI Gene Model | MGI Sequence Detail 6022 C57BL/6J ±  kb
    transcript NM_178005 RefSeq | MGI Sequence Detail 5673 C57BL/6  
    polypeptide Q8BGA3 UniProt | EBI | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009947 leucine-rich repeat transmembrane neuronal protein 2
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR050328 Multifunctional Developmental and Immune Receptor
    • GlyGen
      Q8BGA3 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147278, MGI:2147387
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory