Htatsf1 MGI Mouse Gene Detail - MGI:1919709

Symbol

Htatsf1
Name

HIV TAT specific factor 1
Synonyms

1600023H17Rik, 2600017A12Rik, 2700077B20Rik, TAT-SF1

Feature Type

protein coding gene
IDs

MGI:1919709
NCBI Gene: 72459
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

ChrX:56098943-56112543 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 30.81 cM, cytoband A4
Mapping Data

2 experiments

SNPs within 2kb

259 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919709	protein coding gene	ChrX:56098930-56112543 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035744	protein coding gene	ChrX:52370811-52384411 (+)
A/J	MGP_AJ_G0035727	protein coding gene	ChrX:52567986-52583118 (+)
AKR/J	MGP_AKRJ_G0035647	protein coding gene	ChrX:53963107-53976688 (+)
BALB/cJ	MGP_BALBcJ_G0035714	protein coding gene	ChrX:52019500-52033100 (+)
C3H/HeJ	MGP_C3HHeJ_G0035416	protein coding gene	ChrX:52897138-52910738 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036243	protein coding gene	ChrX:53755515-53769115 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033094	protein coding gene	ChrX:51975457-51989168 (+)
CAST/EiJ	MGP_CASTEiJ_G0034709	protein coding gene	ChrX:38797919-38811485 (+)
CBA/J	MGP_CBAJ_G0035391	protein coding gene	ChrX:55333242-55346842 (+)
DBA/2J	MGP_DBA2J_G0035545	protein coding gene	ChrX:52145953-52159553 (+)
FVB/NJ	MGP_FVBNJ_G0035495	protein coding gene	ChrX:51743387-51756988 (+)
LP/J	MGP_LPJ_G0035633	protein coding gene	ChrX:52955244-52968844 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035531	protein coding gene	ChrX:56869769-56883370 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036259	protein coding gene	ChrX:52403432-52417032 (+)
PWK/PhJ	MGP_PWKPhJ_G0034405	protein coding gene	ChrX:37067700-37081371 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034249	protein coding gene	ChrX:39530552-39544315 (+)
WSB/EiJ	MGP_WSBEiJ_G0034852	protein coding gene	ChrX:51932137-51945746 (+)

Human Ortholog

HTATSF1, HIV-1 Tat specific factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HTATSF1, HIV-1 Tat specific factor 1
Synonyms

dJ196E23.2, TAT-SF1, TATSF1
Links

HGNC:5276

NCBI Gene ID: 27336

neXtProt AC: NX_O43719

UniProt: O43719
Chr Location

Xq26.3; chrX:136497079-136512346 (+) GRCh38

MGI Vertebrate Homology

Htatsf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HTATSF1
Gene Tree

Htatsf1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

7 strains or lines available

Mice homozygous for a conditional allele activated in embryonic stem cells exhibit reduced pluripotency.

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

13
cDNA Data

98
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HTATSF1

Xenbase htatsf1

ZFIN htatsf1

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All Sequences

44
RefSeq

4
UniProt

1
CCDS

CCDS40983.1

Ensembl

ENSMUSG00000067873 (Evidence)
NCBI Gene

72459

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067873	Ensembl Gene Model \| MGI Sequence Detail	13601	C57BL/6J	± kb
transcript	ENSMUST00000088652	Ensembl \| MGI Sequence Detail	2810	Not Applicable
polypeptide	ENSMUSP00000086027	Ensembl \| MGI Sequence Detail	757	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008830 17S U2 SnRNP complex component HTATSF1

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote

IPR034393 TatSF1-like

IPR034392 TatSF1-like, RNA recognition motif 1
GlyGen

Q8BGC0 1 site, 1 O-linked glycan (1 site)

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All nucleic 99

cDNA 98

Primer pair 1

Microarray probesets 6

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MGI:1922893, MGI:1923845

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346696 Wei C, et al., Imprinted X chromosome inactivation at the gamete-to-embryo transition. Mol Cell. 2024 Feb 29;

TSS for Htatsf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5622	ChrX:56098641-56098661 (+)	-292 bp
Tssr161014	ChrX:56098909-56098957 (+)	-10 bp
Tssr161015	ChrX:56099209-56099228 (+)	276 bp
Tssr161016	ChrX:56099240-56099268 (+)	311 bp
Tssr161017	ChrX:56111377-56111388 (+)	12,440 bp
Tssr161018	ChrX:56111391-56111407 (+)	12,456 bp
Tssr161019	ChrX:56111524-56111539 (+)	12,589 bp
Tssr161020	ChrX:56111661-56111674 (+)	12,725 bp
Tssr161021	ChrX:56111855-56111870 (+)	12,920 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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