Eif4b MGI Mouse Gene Detail - MGI:95304 - eukaryotic translation initiation factor 4B

Symbol

Eif4b
Name

eukaryotic translation initiation factor 4B
Synonyms

2310046H11Rik

Feature Type

protein coding gene
IDs

MGI:95304
NCBI Gene: 75705
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:101982208-102005608 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.26 cM
Mapping Data

1 experiment

SNPs within 2kb

504 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95304	protein coding gene	Chr15:101982208-102005608 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022397	protein coding gene	Chr15:104213990-104237260 (+)
A/J	MGP_AJ_G0022359	protein coding gene	Chr15:100133135-100156497 (+)
AKR/J	MGP_AKRJ_G0022334	protein coding gene	Chr15:103162515-103185577 (+)
BALB/cJ	MGP_BALBcJ_G0022363	protein coding gene	Chr15:100176314-100200014 (+)
C3H/HeJ	MGP_C3HHeJ_G0022130	protein coding gene	Chr15:103232581-103255802 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022812	protein coding gene	Chr15:108097257-108125670 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020335	protein coding gene	Chr15:95908389-95932077 (+)
CAST/EiJ	MGP_CASTEiJ_G0021656	protein coding gene	Chr15:104087198-104113702 (+)
CBA/J	MGP_CBAJ_G0022099	protein coding gene	Chr15:111871176-111898743 (+)
DBA/2J	MGP_DBA2J_G0022230	protein coding gene	Chr15:99415951-99441539 (+)
FVB/NJ	MGP_FVBNJ_G0022206	protein coding gene	Chr15:98474616-98497930 (+)
LP/J	MGP_LPJ_G0022299	protein coding gene	Chr15:104376882-104401086 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022228	protein coding gene	Chr15:115478273-115501587 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022824	protein coding gene	Chr15:103183114-103207397 (+)
PWK/PhJ	MGP_PWKPhJ_G0021396	protein coding gene	Chr15:99567669-99591651 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021228	protein coding gene	Chr15:103028313-103054785 (+)
WSB/EiJ	MGP_WSBEiJ_G0021706	protein coding gene	Chr15:103810923-103834487 (+)

Human Ortholog

EIF4B, eukaryotic translation initiation factor 4B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF4B, eukaryotic translation initiation factor 4B
Synonyms

EIF-4B, PRO1843
Links

HGNC:3285

NCBI Gene ID: 1975

neXtProt AC: NX_P23588

UniProt: P23588
Chr Location

12q13.13; chr12:53006282-53042215 (+) GRCh38

MGI Vertebrate Homology

Eif4b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EIF4B
Gene Tree

Eif4b

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References

1 with disease annotations

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Phenotype Summary

29 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

124
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

113
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Eif4b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die between E14.5 and E16.5 and are pale, with severe embryonic dysplasia, small size, and smaller liver.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif4b

ZFIN eif4ba, eif4bb

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All Sequences

119
RefSeq

2
UniProt

8
CCDS

CCDS49737.1

Ensembl

ENSMUSG00000058655 (Evidence)
NCBI Gene

75705

			Length	Strain/Species	Flank
genomic	75705	NCBI Gene Model \| MGI Sequence Detail	23401	C57BL/6J	± kb
transcript	NM_145625	RefSeq \| MGI Sequence Detail	3871	C57BL/6
polypeptide	Q8BGD9	UniProt \| EBI \| MGI Sequence Detail	611	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000006989 eukaryotic translation initiation factor 4B

(term hierarchy)
InterPro Domains

IPR033107 Eukaryotic translation initiation factor 4B, RNA recognition motif

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q8BGD9 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 22

cDNA 22

Microarray probesets 4

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MGD-MRK-9338, MGI:1922955, MGI:2146118, MGI:2146304

Summaries

All 61

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879

TSS for Eif4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133316	Chr15:101982074-101982077 (+)	-132 bp
Tssr133317	Chr15:101982079-101982089 (+)	-124 bp
Tssr133318	Chr15:101982326-101982338 (+)	124 bp
Tssr133319	Chr15:101982350-101982369 (+)	152 bp
Tssr133321	Chr15:101998404-101998423 (+)	16,206 bp
Tssr133322	Chr15:102003741-102003756 (+)	21,541 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24