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Trim6 Gene Detail
Summary
  • Symbol
    Trim6
  • Name
    tripartite motif-containing 6
  • Synonyms
    C430046K18Rik, D7Ertd684e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137352
    NCBI Gene: 94088
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:103868002-103884359 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.55 cM, cytoband F1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137352
 protein coding gene Chr7:103868000-103884359 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032708
 protein coding gene Chr7:107446639-107461629 (+)
A/J MGP_AJ_G0032683
 protein coding gene Chr7:104636449-104651423 (+)
AKR/J MGP_AKRJ_G0032616
 protein coding gene Chr7:107159082-107174310 (+)
BALB/cJ MGP_BALBcJ_G0032693
 protein coding gene Chr7:104369347-104384367 (+)
C3H/HeJ MGP_C3HHeJ_G0032404
 protein coding gene Chr7:107516578-107532861 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033189
 protein coding gene Chr7:111474602-111504219 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030184
 protein coding gene Chr7:106714205-106727447 (+)
CAST/EiJ MGP_CASTEiJ_G0031733
 protein coding gene Chr7:99162586-99190040 (+)
CBA/J MGP_CBAJ_G0032372
 protein coding gene Chr7:115421537-115440010 (+)
DBA/2J MGP_DBA2J_G0032526
 protein coding gene Chr7:102969043-102984246 (+)
FVB/NJ MGP_FVBNJ_G0032479
 protein coding gene Chr7:102677574-102693693 (+)
LP/J MGP_LPJ_G0032619
 protein coding gene Chr7:108776059-108794933 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032513
 protein coding gene Chr7:116803947-116820365 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033216
 protein coding gene Chr7:106361295-106378600 (+)
PWK/PhJ MGP_PWKPhJ_G0031447
 protein coding gene Chr7:95960485-95975862 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031292
 protein coding gene Chr7:93579407-93603225 (+)
WSB/EiJ MGP_WSBEiJ_G0031848
 protein coding gene Chr7:107101355-107121549 (+)



Homology
more
  • Human Ortholog
    TRIM6, tripartite motif containing 6
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM6, tripartite motif containing 6
  • Synonyms
    RNF89
  • Links
    NCBI Gene ID: 117854
    neXtProt AC: NX_Q9C030
    UniProt: Q9C030

  • Chr Location
    11p15.4; chr11:5596109-5612958 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Bone marrow-derived dendritic cells and MEFs from homozygous null mice show attenuated recombinant Ebola virus replication.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    15
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 94088 NCBI Gene Model | MGI Sequence Detail 16358 C57BL/6J ±  kb
transcript NM_001013616 RefSeq | MGI Sequence Detail 3827 ZRU/MplStud  
polypeptide Q8BGE7 UniProt | EBI | MGI Sequence Detail 488 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1289200, MGI:1924853
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory