Vgll2 MGI Mouse Gene Detail - MGI:2447460 - vestigial like family member 2

Symbol

Vgll2
Name

vestigial like family member 2
Synonyms

C130057C21Rik, Vgl-2, Vito1, VITO-1

Feature Type

protein coding gene
IDs

MGI:2447460
NCBI Gene: 215031
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:51898598-51904567 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 26.16 cM
Mapping Data

1 experiment

SNPs within 2kb

222 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447460	protein coding gene	Chr10:51898598-51904567 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017220	protein coding gene	Chr10:51169037-51174948 (+)
A/J	MGP_AJ_G0017196	protein coding gene	Chr10:49667390-49673359 (+)
AKR/J	MGP_AKRJ_G0017155	protein coding gene	Chr10:50594094-50600053 (+)
BALB/cJ	MGP_BALBcJ_G0017157	protein coding gene	Chr10:49762495-49768464 (+)
C3H/HeJ	MGP_C3HHeJ_G0016979	protein coding gene	Chr10:50850952-50856909 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017616	protein coding gene	Chr10:52776630-52782599 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015310	protein coding gene	Chr10:46919607-46925538 (+)
CAST/EiJ	MGP_CASTEiJ_G0016553	protein coding gene	Chr10:50995549-51001480 (+)
CBA/J	MGP_CBAJ_G0016952	protein coding gene	Chr10:55043464-55049433 (+)
DBA/2J	MGP_DBA2J_G0017057	protein coding gene	Chr10:49089531-49097725 (+)
FVB/NJ	MGP_FVBNJ_G0017051	protein coding gene	Chr10:48437081-48443040 (+)
LP/J	MGP_LPJ_G0017132	protein coding gene	Chr10:51237733-51243650 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017080	protein coding gene	Chr10:56972927-56978888 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017651	protein coding gene	Chr10:50538062-50543965 (+)
PWK/PhJ	MGP_PWKPhJ_G0016334	protein coding gene	Chr10:48956126-48962176 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016119	protein coding gene	Chr10:50167014-50173850 (+)
WSB/EiJ	MGP_WSBEiJ_G0016618	protein coding gene	Chr10:50752644-50758605 (+)

Human Ortholog

VGLL2, vestigial like family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VGLL2, vestigial like family member 2
Synonyms

VGL2, VITO1
Links

HGNC:20232

NCBI Gene ID: 245806

neXtProt AC: NX_Q8N8G2

UniProt: Q8N8G2
Chr Location

6q22.1; chr6:117265558-117273630 (+) GRCh38

MGI Vertebrate Homology

Vgll2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VGLL2
Gene Tree

Vgll2

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Vgll2
Incidental Mutations

CvDC
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal skeletal muscle fiber type ratio and impaired exercise endurance.

less

All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

64
cDNA Data

5
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vgll2

less

All Sequences

33
RefSeq

4
UniProt

2
CCDS

CCDS23837.1, CCDS78812.1

Ensembl

ENSMUSG00000049641 (Evidence)
NCBI Gene

215031

			Length	Strain/Species	Flank
genomic	215031	NCBI Gene Model \| MGI Sequence Detail	5970	C57BL/6J	± kb
transcript	NM_153786	RefSeq \| MGI Sequence Detail	1667	C57BL/6
polypeptide	Q8BGW8	UniProt \| EBI \| MGI Sequence Detail	322	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000017291 transcription cofactor vestigial-like protein 2

(term hierarchy)
InterPro Domains

IPR011520 Vestigial family

less

All nucleic 9

Genomic 1

cDNA 5

Primer pair 1

Other 2

Microarray probesets 1

less

MGI:2443345

Summaries

All 38

Developmental Gene Expression 11

Gene Ontology 4

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539

TSS for Vgll2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93295	Chr10:51898616-51898630 (+)	25 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24