Bmp3 MGI Mouse Gene Detail - MGI:88179 - bone morphogenetic protein 3

Symbol

Bmp3
Name

bone morphogenetic protein 3
Synonyms

9530029I04Rik

Feature Type

protein coding gene
IDs

MGI:88179
NCBI Gene: 110075
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:99002274-99031912 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 48.24 cM
Mapping Data

6 experiments

SNPs within 2kb

950 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88179	protein coding gene	Chr5:99002274-99032255 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029776	protein coding gene	Chr5:100237081-100267054 (+)
A/J	MGP_AJ_G0029742	protein coding gene	Chr5:96529294-96560464 (+)
AKR/J	MGP_AKRJ_G0029688	protein coding gene	Chr5:99722007-99753434 (+)
BALB/cJ	MGP_BALBcJ_G0029752	protein coding gene	Chr5:97537498-97567857 (+)
C3H/HeJ	MGP_C3HHeJ_G0029475	protein coding gene	Chr5:100058422-100089699 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030207	protein coding gene	Chr5:104453053-104485921 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027442	protein coding gene	Chr5:91817418-91847432 (+)
CAST/EiJ	MGP_CASTEiJ_G0028886	protein coding gene	Chr5:98687115-98719823 (+)
CBA/J	MGP_CBAJ_G0029445	protein coding gene	Chr5:108045147-108075180 (+)
DBA/2J	MGP_DBA2J_G0029589	protein coding gene	Chr5:96715527-96745732 (+)
FVB/NJ	MGP_FVBNJ_G0029548	protein coding gene	Chr5:95528015-95558413 (+)
LP/J	MGP_LPJ_G0029677	protein coding gene	Chr5:100845772-100879175 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029577	protein coding gene	Chr5:113167875-113200073 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030240	protein coding gene	Chr5:99167731-99197651 (+)
PWK/PhJ	MGP_PWKPhJ_G0028604	protein coding gene	Chr5:95145744-95176565 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028439	protein coding gene	Chr5:96858171-96889897 (+)
WSB/EiJ	MGP_WSBEiJ_G0028964	protein coding gene	Chr5:99505054-99535043 (+)

Human Ortholog

BMP3, bone morphogenetic protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BMP3, bone morphogenetic protein 3
Synonyms

BMP-3A
Links

HGNC:1070

NCBI Gene ID: 651

neXtProt AC: NX_P12645

UniProt: P12645
Chr Location

4q21.21; chr4:81030708-81057627 (+) GRCh38

MGI Vertebrate Homology

Bmp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BMP3
Protein SuperFamily

BMP3/GDF10
Gene Tree

Bmp3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

3 involving Bmp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in increased bone density.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1120
Tissues

158
cDNA Data

19
Literature Summary

37

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BMP3

Xenbase bmp3

ZFIN bmp3

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All Sequences

42
RefSeq

4
UniProt

4
CCDS

CCDS19458.1, CCDS80345.1

Ensembl

ENSMUSG00000029335 (Evidence)
NCBI Gene

110075

			Length	Strain/Species	Flank
genomic	110075	NCBI Gene Model \| MGI Sequence Detail	29639	C57BL/6J	± kb
transcript	NM_001310677	RefSeq \| MGI Sequence Detail	6302	ZRU/MplStud
polypeptide	Q8BHE5	UniProt \| EBI \| MGI Sequence Detail	468	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004774 bone morphogenetic protein 3

(term hierarchy)
InterPro Domains

IPR017197 Bone morphogenetic protein 3/3B

IPR029034 Cystine-knot cytokine

IPR001111 TGF-beta, propeptide

IPR017948 Transforming growth factor beta, conserved site

IPR001839 Transforming growth factor-beta, C-terminal

IPR015615 Transforming growth factor-beta-related
GlyGen

Q8BHE5 5 sites, 3 N-linked glycans (4 sites)

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All nucleic 27

cDNA 20

Primer pair 3

Other 4

Microarray probesets 1

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MGD-MRK-1601, MGI:2442431

Summaries

All 79

Developmental Gene Expression 37

Gene Ontology 7

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:327415 Jing J, et al., Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803

TSS for Bmp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47449	Chr5:99002267-99002288 (+)	4 bp
Tssr47450	Chr5:99002293-99002325 (+)	35 bp
Tssr47451	Chr5:99002332-99002346 (+)	65 bp
Tssr47452	Chr5:99002412-99002421 (+)	143 bp
Tssr47453	Chr5:99002640-99002668 (+)	380 bp
Tssr47454	Chr5:99002690-99002701 (+)	422 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24