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Elmo2 Gene Detail
Summary
  • Symbol
    Elmo2
  • Name
    engulfment and cell motility 2
  • Synonyms
    1190002F24Rik, CED-12, mKIAA1834
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153045
    NCBI Gene: 140579
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:165129951-165168399 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1214 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153045
 protein coding gene Chr2:165129951-165168421 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026890
 protein coding gene Chr2:170838680-170876927 (-)
A/J MGP_AJ_G0026857
 protein coding gene Chr2:163838282-163876288 (-)
AKR/J MGP_AKRJ_G0026828
 protein coding gene Chr2:168717868-168758693 (-)
BALB/cJ MGP_BALBcJ_G0026866
 protein coding gene Chr2:164202371-164241709 (-)
C3H/HeJ MGP_C3HHeJ_G0026608
 protein coding gene Chr2:169077145-169116911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027313
 protein coding gene Chr2:175780953-175819138 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024684
 protein coding gene Chr2:157238221-157279459 (-)
CAST/EiJ MGP_CASTEiJ_G0026066
 protein coding gene Chr2:169504012-169543814 (-)
CBA/J MGP_CBAJ_G0026585
 protein coding gene Chr2:182177818-182218431 (-)
DBA/2J MGP_DBA2J_G0026723
 protein coding gene Chr2:162996694-163035463 (-)
FVB/NJ MGP_FVBNJ_G0026689
 protein coding gene Chr2:161439213-161478659 (-)
LP/J MGP_LPJ_G0026825
 protein coding gene Chr2:170888828-170927178 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026708
 protein coding gene Chr2:185689391-185729713 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027370
 protein coding gene Chr2:168615271-168653569 (-)
PWK/PhJ MGP_PWKPhJ_G0025803
 protein coding gene Chr2:162606562-162645335 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025604
 protein coding gene Chr2:167530881-167568475 (-)
WSB/EiJ MGP_WSBEiJ_G0026139
 protein coding gene Chr2:169511787-169551548 (-)



Homology
more
  • Human Ortholog
    ELMO2, engulfment and cell motility 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELMO2, engulfment and cell motility 2
  • Synonyms
    CED-12, CED12, Ced-12A, ELMO-2, VMPI
  • Links
    NCBI Gene ID: 63916
    neXtProt AC: NX_Q96JJ3
    UniProt: Q96JJ3

  • Chr Location
    20q13.12; chr20:46366050-46432985 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit no gross abnormalities with normal muscle morphology and regeneration. Mice homozygous for an allele lacking the inhibiting domain exhibit enhanced skeletal muscle regeneration. Mice homozygous for an allele lacking the RAS-binding domain exhibit impaired skeletal muscle regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    143
  • cDNA Data
    16
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017670 Ensembl Gene Model | MGI Sequence Detail 38449 C57BL/6J ±  kb
transcript ENSMUST00000071699 Ensembl | MGI Sequence Detail 3247 Not Applicable  
polypeptide ENSMUSP00000071619 Ensembl | MGI Sequence Detail 798 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1921247
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:334814 Tang YC, et al., Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis. Cell Rep. 2023 Mar 28;42(3):112202
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory