Snx14 MGI Mouse Gene Detail - MGI:2155664

Symbol

Snx14
Name

sorting nexin 14
Synonyms

C330035N22Rik, YR-14

Feature Type

protein coding gene
IDs

MGI:2155664
NCBI Gene: 244962
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:88258805-88320982 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 47.24 cM
Mapping Data

1 experiment

SNPs within 2kb

1868 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155664	protein coding gene	Chr9:88258800-88321011 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035107	protein coding gene	Chr9:89250584-89316678 (-)
A/J	MGP_AJ_G0035088	protein coding gene	Chr9:86136108-86198662 (-)
AKR/J	MGP_AKRJ_G0035016	protein coding gene	Chr9:88151513-88213503 (-)
BALB/cJ	MGP_BALBcJ_G0035076	protein coding gene	Chr9:85749966-85812057 (-)
C3H/HeJ	MGP_C3HHeJ_G0034788	protein coding gene	Chr9:88624533-88691383 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035600	protein coding gene	Chr9:91660072-91726901 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032507	protein coding gene	Chr9:84832498-84891461 (-)
CAST/EiJ	MGP_CASTEiJ_G0034106	protein coding gene	Chr9:89069980-89144154 (-)
CBA/J	MGP_CBAJ_G0034761	protein coding gene	Chr9:94871169-94940108 (-)
DBA/2J	MGP_DBA2J_G0034919	protein coding gene	Chr9:85662229-85724510 (-)
FVB/NJ	MGP_FVBNJ_G0034862	protein coding gene	Chr9:84712344-84775169 (-)
LP/J	MGP_LPJ_G0035000	protein coding gene	Chr9:89449268-89512507 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034904	protein coding gene	Chr9:96502573-96571910 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035620	protein coding gene	Chr9:88293141-88357994 (-)
PWK/PhJ	MGP_PWKPhJ_G0033810	protein coding gene	Chr9:85811701-85876920 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033646	protein coding gene	Chr9:88463833-88531445 (-)
WSB/EiJ	MGP_WSBEiJ_G0034223	protein coding gene	Chr9:88324139-88392545 (-)

Human Ortholog

SNX14, sorting nexin 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX14, sorting nexin 14
Synonyms

RGS-PX2, SCAR20
Links

HGNC:14977

NCBI Gene ID: 57231

neXtProt AC: NX_Q9Y5W7

UniProt: Q9Y5W7
Chr Location

6q14.3; chr6:85504776-85594156 (-) GRCh38

MGI Vertebrate Homology

Snx14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNX14
Gene Tree

Snx14

Diseases

1 with human SNX14 associations

				Human Disease	Mouse Models
				autosomal recessive spinocerebellar ataxia 20 IDs autosomal recessive spinocerebellar ataxia 20 DOID:0080066 OMIM:616354

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Snx14
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx14

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All Sequences

63
RefSeq

6
UniProt

8
CCDS

CCDS23387.2

Ensembl

ENSMUSG00000032422 (Evidence)
NCBI Gene

244962

			Length	Strain/Species	Flank
genomic	244962	NCBI Gene Model \| MGI Sequence Detail	62178	C57BL/6J	± kb
transcript	NM_001359958	RefSeq \| MGI Sequence Detail	3109	C57BL/6
polypeptide	Q8BHY8	UniProt \| EBI \| MGI Sequence Detail	964	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000015363 sorting nexin-14

(term hierarchy)
InterPro Domains

IPR003114 Phox-associated domain

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR037892 SNX14, RGS domain

IPR037436 Sorting nexin-14, PX domain

IPR013937 Sorting nexin, C-terminal

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 3

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MGI:2443156

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 7
Earliest

J:70707 Carroll P, et al., Sorting nexin-14, a gene expressed in motoneurons trapped by an in vitro preselection method. Dev Dyn. 2001 Aug;221(4):431-42
Latest

J:353340 Zhou Y, et al., Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency. JCI Insight. 2024 Apr 16;9(10)

TSS for Snx14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90818	Chr9:88320993-88321000 (-)	-15 bp
Tssr90817	Chr9:88320962-88320989 (-)	6 bp
Tssr90816	Chr9:88320938-88320945 (-)	40 bp
Tssr90815	Chr9:88318653-88318677 (-)	2,317 bp
Tssr90814	Chr9:88262297-88262315 (-)	58,676 bp
Tssr90813	Chr9:88262261-88262286 (-)	58,708 bp
Tssr90812	Chr9:88262237-88262241 (-)	58,743 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24