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Mal2 Gene Detail
Summary
  • Symbol
    Mal2
  • Name
    mal, T cell differentiation protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146021
    NCBI Gene: 105853
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54434762-54466242 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 21.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1002 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146021
 protein coding gene Chr15:54434588-54466243 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021848
 protein coding gene Chr15:53615008-53648361 (+)
A/J MGP_AJ_G0021808
 protein coding gene Chr15:51491039-51522251 (+)
AKR/J MGP_AKRJ_G0021789
 protein coding gene Chr15:52945927-52976996 (+)
BALB/cJ MGP_BALBcJ_G0021815
 protein coding gene Chr15:51723097-51754806 (+)
C3H/HeJ MGP_C3HHeJ_G0021589
 protein coding gene Chr15:53032716-53066223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022254
 protein coding gene Chr15:55712696-55744091 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019791
 protein coding gene Chr15:48749971-48780981 (+)
CAST/EiJ MGP_CASTEiJ_G0021106
 protein coding gene Chr15:53604282-53635052 (+)
CBA/J MGP_CBAJ_G0021558
 protein coding gene Chr15:57717826-57753324 (+)
DBA/2J MGP_DBA2J_G0021682
 protein coding gene Chr15:51384312-51429570 (+)
FVB/NJ MGP_FVBNJ_G0021660
 protein coding gene Chr15:50526321-50557343 (+)
LP/J MGP_LPJ_G0021752
 protein coding gene Chr15:53419771-53451409 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021684
 protein coding gene Chr15:62776675-62808280 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022277
 protein coding gene Chr15:53296645-53328677 (+)
PWK/PhJ MGP_PWKPhJ_G0020851
 protein coding gene Chr15:51454766-51486577 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020688
 protein coding gene Chr15:53031722-53062719 (+)
WSB/EiJ MGP_WSBEiJ_G0021161
 protein coding gene Chr15:53281314-53314224 (+)



Homology
more
  • Human Ortholog
    MAL2, mal, T cell differentiation protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAL2, mal, T cell differentiation protein 2
  • Links
    NCBI Gene ID: 114569
    neXtProt AC: NX_Q969L2
    UniProt: Q969L2

  • Chr Location
    8q24.12; chr8:119165034-119245673 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    3
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Mal2
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    15
  • cDNA Data
    21
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 105853 NCBI Gene Model | MGI Sequence Detail 31481 C57BL/6J ±  kb
transcript NM_178920 RefSeq | MGI Sequence Detail 2775 C57BL/6  
polypeptide Q8BI08 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:311246 Zhu M, et al., Identification of KIAA0513 and Other Hub Genes Associated With Alzheimer Disease Using Weighted Gene Coexpression Network Analysis. Front Genet. 2020;11:981
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory