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Cd99l2 Gene Detail
Summary
  • Symbol
    Cd99l2
  • Name
    CD99 antigen-like 2
  • Synonyms
    Mic2l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177151
    NCBI Gene: 171486
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:70463666-70536455 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 36.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1698 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177151
 protein coding gene ChrX:70463666-70536467 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035783
 protein coding gene ChrX:67069839-67145339 (-)
A/J MGP_AJ_G0035766
 protein coding gene ChrX:67301609-67380409 (-)
AKR/J MGP_AKRJ_G0035688
 protein coding gene ChrX:69102600-69181476 (-)
BALB/cJ MGP_BALBcJ_G0035753
 protein coding gene ChrX:66387722-66461999 (-)
C3H/HeJ MGP_C3HHeJ_G0035456
 protein coding gene ChrX:67588266-67661346 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036283
 protein coding gene ChrX:69110273-69186879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033131
 protein coding gene ChrX:66561419-66643259 (-)
CAST/EiJ MGP_CASTEiJ_G0034748
 protein coding gene ChrX:52976361-53054419 (-)
CBA/J MGP_CBAJ_G0035431
 protein coding gene ChrX:71038055-71114702 (-)
DBA/2J MGP_DBA2J_G0035584
 protein coding gene ChrX:66810837-66883903 (-)
FVB/NJ MGP_FVBNJ_G0035535
 protein coding gene ChrX:66177810-66251896 (-)
LP/J MGP_LPJ_G0035673
 protein coding gene ChrX:67911846-67988644 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035570
 protein coding gene ChrX:73563348-73642691 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036304
 protein coding gene ChrX:66930179-67008969 (-)
PWK/PhJ MGP_PWKPhJ_G0034448
 protein coding gene ChrX:51018334-51091696 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034284
 protein coding gene ChrX:53875264-53955823 (-)
WSB/EiJ MGP_WSBEiJ_G0034890
 protein coding gene ChrX:66261184-66336876 (-)



Homology
more
  • Human Ortholog
    CD99L2, CD99 molecule like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD99L2, CD99 molecule like 2
  • Synonyms
    CD99B, MIC2L1
  • Links
    NCBI Gene ID: 83692
    neXtProt AC: NX_Q8TCZ2
    UniProt: Q8TCZ2

  • Chr Location
    Xq28; chrX:150766336-150898816 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO in endothelial cells hinders neutrophil and T cell extravasation and reduces the delayed-type (type IV) hypersensitivity reaction in inflamed tissue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    85
  • cDNA Data
    12
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035776 Ensembl Gene Model | MGI Sequence Detail 72790 C57BL/6J ±  kb
transcript ENSMUST00000037391 Ensembl | MGI Sequence Detail 3600 Not Applicable  
polypeptide ENSMUSP00000042606 Ensembl | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2148021
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:266045 Samus M, et al., CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. J Leukoc Biol. 2018 Oct;104(4):787-797
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory