Nup93 MGI Mouse Gene Detail - MGI:1919055

Symbol

Nup93
Name

nucleoporin 93
Synonyms

2410008G02Rik

Feature Type

protein coding gene
IDs

MGI:1919055
NCBI Gene: 71805
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:94941203-95043858 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 46.40 cM
Mapping Data

1 experiment

SNPs within 2kb

2445 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919055	protein coding gene	Chr8:94941192-95043858 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033958	protein coding gene	Chr8:95623297-95730165 (+)
A/J	MGP_AJ_G0033941	protein coding gene	Chr8:91898514-91998862 (+)
AKR/J	MGP_AKRJ_G0033867	protein coding gene	Chr8:94420974-94520244 (+)
BALB/cJ	MGP_BALBcJ_G0033933	protein coding gene	Chr8:91991400-92093165 (+)
C3H/HeJ	MGP_C3HHeJ_G0033643	protein coding gene	Chr8:95121808-95226805 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034454	protein coding gene	Chr8:99117301-99225144 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031395	protein coding gene	Chr8:85704215-85814964 (+)
CAST/EiJ	MGP_CASTEiJ_G0032975	protein coding gene	Chr8:94713854-94823789 (+)
CBA/J	MGP_CBAJ_G0033619	protein coding gene	Chr8:102408382-102514490 (+)
DBA/2J	MGP_DBA2J_G0033773	protein coding gene	Chr8:91367222-91467946 (+)
FVB/NJ	MGP_FVBNJ_G0033720	protein coding gene	Chr8:90332625-90435096 (+)
LP/J	MGP_LPJ_G0033865	protein coding gene	Chr8:95771247-95880367 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033762	protein coding gene	Chr8:104706072-104812039 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034472	protein coding gene	Chr8:94578319-94681017 (+)
PWK/PhJ	MGP_PWKPhJ_G0032677	protein coding gene	Chr8:90731898-90845179 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032514	protein coding gene	Chr8:93403045-93507183 (+)
WSB/EiJ	MGP_WSBEiJ_G0033087	protein coding gene	Chr8:95097395-95201388 (+)

Human Ortholog

NUP93, nucleoporin 93

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP93, nucleoporin 93
Synonyms

NIC96
Links

HGNC:28958

NCBI Gene ID: 9688

neXtProt AC: NX_Q8N1F7

UniProt: Q8N1F7
Chr Location

16q13; chr16:56730118-56850286 (+) GRCh38

MGI Vertebrate Homology

Nup93 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP93
Gene Tree

Nup93

Diseases

1 with human NUP93 associations

				Human Disease	Mouse Models
				nephrotic syndrome type 12 IDs nephrotic syndrome type 12 DOID:0080387 OMIM:616892

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

2
Gene trapped

24
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths with no inner cell mass colony or trophoblast giant cells after 3 days in culture.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup93

ZFIN nup93

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All Sequences

76
RefSeq

28
UniProt

4
CCDS

CCDS22540.1, CCDS90438.1

Ensembl

ENSMUSG00000032939 (Evidence)
NCBI Gene

71805

			Length	Strain/Species	Flank
genomic	71805	NCBI Gene Model \| MGI Sequence Detail	102656	C57BL/6J	± kb
transcript	NM_172410	RefSeq \| MGI Sequence Detail	2958	C57BL/6
polypeptide	Q8BJ71	UniProt \| EBI \| MGI Sequence Detail	819	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011525 nuclear pore complex protein Nup93

(term hierarchy)
InterPro Domains

IPR007231 Nucleoporin interacting component Nup93/Nic96
GlyGen

Q8BJ71 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 38

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349709 Nguyen TD, et al., Nucleoporin93 limits Yap activity to prevent endothelial cell senescence. Aging Cell. 2024 Apr;23(4):e14095

TSS for Nup93:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78829	Chr8:94941175-94941186 (+)	-22 bp
Tssr78830	Chr8:94941195-94941236 (+)	13 bp
Tssr78832	Chr8:94954162-94954239 (+)	12,998 bp
Tssr78833	Chr8:94954280-94954301 (+)	13,088 bp
Tssr78834	Chr8:94993453-94993466 (+)	52,257 bp
Tssr78835	Chr8:94993714-94993729 (+)	52,519 bp
Tssr78836	Chr8:94993733-94993779 (+)	52,553 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24