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Eme1 Gene Detail
Summary
  • Symbol
    Eme1
  • Name
    essential meiotic structure-specific endonuclease 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576783
    NCBI Gene: 268465
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94535798-94544611 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3576783
 protein coding gene Chr11:94535798-94544790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018964
 protein coding gene Chr11:96754192-96762836 (-)
A/J MGP_AJ_G0018932
 protein coding gene Chr11:92873112-92883525 (-)
AKR/J MGP_AKRJ_G0018902
 protein coding gene Chr11:95764895-95773877 (-)
BALB/cJ MGP_BALBcJ_G0018905
 protein coding gene Chr11:93324217-93332847 (-)
C3H/HeJ MGP_C3HHeJ_G0018719
 protein coding gene Chr11:95846280-95855187 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019357
 protein coding gene Chr11:99785071-99799211 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016988
 protein coding gene Chr11:90365194-90374596 (-)
CAST/EiJ MGP_CASTEiJ_G0018274
 protein coding gene Chr11:96572679-96584979 (-)
CBA/J MGP_CBAJ_G0018690
 protein coding gene Chr11:103915100-103927234 (-)
DBA/2J MGP_DBA2J_G0018798
 protein coding gene Chr11:92455088-92463768 (-)
FVB/NJ MGP_FVBNJ_G0018787
 protein coding gene Chr11:91872187-91881360 (-)
LP/J MGP_LPJ_G0018868
 protein coding gene Chr11:97295344-97304036 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018814
 protein coding gene Chr11:103917894-103928469 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019397
 protein coding gene Chr11:96004036-96013138 (-)
PWK/PhJ MGP_PWKPhJ_G0018044
 protein coding gene Chr11:93389241-93398420 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017834
 protein coding gene Chr11:95669000-95678597 (-)
WSB/EiJ MGP_WSBEiJ_G0018323
 protein coding gene Chr11:95876214-95885179 (-)



Homology
more
  • Human Ortholog
    EME1, essential meiotic structure-specific endonuclease 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EME1, essential meiotic structure-specific endonuclease 1
  • Synonyms
    MMS4L, SLX2A
  • Links
    NCBI Gene ID: 146956
    neXtProt AC: NX_Q96AY2
    UniProt: Q96AY2

  • Chr Location
    17q21.33; chr17:50373220-50381483 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    29
  • cDNA Data
    5
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268465 NCBI Gene Model | MGI Sequence Detail 8814 C57BL/6J ±  kb
    transcript NM_001379688 RefSeq | MGI Sequence Detail 2280 C57BL/6  
    polypeptide Q8BJW7 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory