Csnk1a1 MGI Mouse Gene Detail - MGI:1934950

Symbol

Csnk1a1
Name

casein kinase 1, alpha 1
Synonyms

2610208K14Rik, 4632404G05Rik, 5430427P18Rik, CK1a

Feature Type

protein coding gene
IDs

MGI:1934950
NCBI Gene: 93687
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr18:61688345-61723132 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 34.62 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

592 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934950	protein coding gene	Chr18:61687307-61723391 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024481	protein coding gene	Chr18:61449711-61486693 (+)
A/J	MGP_AJ_G0024448	protein coding gene	Chr18:58812253-58846969 (+)
AKR/J	MGP_AKRJ_G0024418	protein coding gene	Chr18:60419160-60453901 (+)
BALB/cJ	MGP_BALBcJ_G0024447	protein coding gene	Chr18:58936692-58971391 (+)
C3H/HeJ	MGP_C3HHeJ_G0024215	protein coding gene	Chr18:60665750-60701811 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024894	protein coding gene	Chr18:63117222-63152689 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022325	protein coding gene	Chr18:58358795-58393308 (+)
CAST/EiJ	MGP_CASTEiJ_G0023688	protein coding gene	Chr18:60537378-60575188 (+)
CBA/J	MGP_CBAJ_G0024185	protein coding gene	Chr18:65149641-65198285 (+)
DBA/2J	MGP_DBA2J_G0024315	protein coding gene	Chr18:58474725-58509442 (+)
FVB/NJ	MGP_FVBNJ_G0024281	protein coding gene	Chr18:57884979-57920918 (+)
LP/J	MGP_LPJ_G0024398	protein coding gene	Chr18:61301579-61337545 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024310	protein coding gene	Chr18:66740414-66776378 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024941	protein coding gene	Chr18:60634235-60668886 (+)
PWK/PhJ	MGP_PWKPhJ_G0023431	protein coding gene	Chr18:58710947-58746457 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023237	protein coding gene	Chr18:60867420-60903529 (+)
WSB/EiJ	MGP_WSBEiJ_G0023752	protein coding gene	Chr18:60490659-60525388 (+)

Human Ortholog

CSNK1A1, casein kinase 1 alpha 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSNK1A1, casein kinase 1 alpha 1
Synonyms

CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975
Links

HGNC:2451

NCBI Gene ID: 1452

neXtProt AC: NX_P48729

UniProt: P48729
Chr Location

5q32; chr5:149492982-149551471 (-) GRCh38

MGI Vertebrate Homology

Csnk1a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CSNK1A1
Gene Tree

Csnk1a1

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Phenotype Summary

37 phenotypes from 3 alleles in 5 genetic backgrounds
12 phenotypes from multigenic genotypes
6 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Endonuclease-mediated

1
Gene trapped

34
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality.

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All GO Annotations

55
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

80
cDNA Data

342
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase csnk1a1

ZFIN csnk1a1

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All Sequences

124
RefSeq

20
UniProt

11
CCDS

CCDS37838.1, CCDS89251.1, CCDS89252.1, CCDS89254.1

Ensembl

ENSMUSG00000024576 (Evidence)
NCBI Gene

93687

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024576	Ensembl Gene Model \| MGI Sequence Detail	34788	C57BL/6J	± kb
transcript	ENSMUST00000166990	Ensembl \| MGI Sequence Detail	1860	Not Applicable
polypeptide	ENSMUSP00000131687	Ensembl \| MGI Sequence Detail	374	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000005943 casein kinase I isoform alpha

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR050235 Casein Kinase 1 Ser/Thr Protein Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 347

cDNA 343

Primer pair 3

Other 1

Microarray probesets 8

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MGI:1914042, MGI:1915311, MGI:1926085

Summaries

All 77

Developmental Gene Expression 9

Gene Ontology 16

Phenotypes 23
Earliest

J:46689 McInnes C, et al., Tissue-specific distribution of mouse casein kinase I alpha mRNA. DNA Seq. 1997;8(1-2):55-7
Latest

J:353442 Luo X, et al., Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells. BMC Biol. 2024 Aug 26;22(1):176

TSS for Csnk1a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5347	Chr18:61686653-61686656 (+)	-1,690 bp
Tssr151465	Chr18:61688296-61688310 (+)	-42 bp
Tssr151466	Chr18:61688329-61688361 (+)	0 bp
Tssr151467	Chr18:61688379-61688416 (+)	53 bp
Tssr151468	Chr18:61688777-61688822 (+)	455 bp
Tssr151469	Chr18:61689004-61689071 (+)	693 bp
Tssr151470	Chr18:61699211-61699217 (+)	10,869 bp
Tssr151471	Chr18:61701415-61701432 (+)	13,079 bp
Tssr151472	Chr18:61709245-61709250 (+)	20,903 bp
Tssr151473	Chr18:61720545-61720566 (+)	32,211 bp
Tssr151474	Chr18:61720640-61720691 (+)	32,321 bp
Tssr151475	Chr18:61722286-61722299 (+)	33,948 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24