Srrm4 MGI Mouse Gene Detail - MGI:1916205 - serine/arginine repetitive matrix 4

Symbol

Srrm4
Name

serine/arginine repetitive matrix 4
Synonyms

1500001A10Rik, B230202K19Rik, bv, flopsy, fp, mKIAA1853, nSR100

Feature Type

protein coding gene
IDs

MGI:1916205
NCBI Gene: 68955
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:116577334-116729876 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.45 cM, cytoband F
Mapping Data

6 experiments

SNPs within 2kb

4547 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916205	protein coding gene	Chr5:116577331-116729882 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029982	protein coding gene	Chr5:119438180-119606779 (-)
A/J	MGP_AJ_G0029946	protein coding gene	Chr5:114624772-114781349 (-)
AKR/J	MGP_AKRJ_G0029885	protein coding gene	Chr5:118312374-118477593 (-)
BALB/cJ	MGP_BALBcJ_G0029957	protein coding gene	Chr5:116035123-116192350 (-)
C3H/HeJ	MGP_C3HHeJ_G0029677	protein coding gene	Chr5:118827736-118991709 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030412	protein coding gene	Chr5:123992199-124165328 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027638	protein coding gene	Chr5:109400118-109557372 (-)
CAST/EiJ	MGP_CASTEiJ_G0029086	protein coding gene	Chr5:117806272-117983715 (-)
CBA/J	MGP_CBAJ_G0029645	protein coding gene	Chr5:128768233-128943232 (-)
DBA/2J	MGP_DBA2J_G0029795	protein coding gene	Chr5:114721891-114877945 (-)
FVB/NJ	MGP_FVBNJ_G0029751	protein coding gene	Chr5:113554562-113715759 (-)
LP/J	MGP_LPJ_G0029883	protein coding gene	Chr5:119955943-120116717 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029782	protein coding gene	Chr5:133053864-133230263 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030453	protein coding gene	Chr5:117818513-117976080 (-)
PWK/PhJ	MGP_PWKPhJ_G0028799	protein coding gene	Chr5:113385049-113542244 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028637	protein coding gene	Chr5:115355460-115545952 (-)
WSB/EiJ	MGP_WSBEiJ_G0029161	protein coding gene	Chr5:118409086-118572152 (-)

Human Ortholog

SRRM4, serine/arginine repetitive matrix 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRRM4, serine/arginine repetitive matrix 4
Synonyms

KIAA1853, MU-MB-2.76, nSR100
Links

HGNC:29389

NCBI Gene ID: 84530

neXtProt AC: NX_A7MD48

UniProt: A7MD48
Chr Location

12q24.23; chr12:118981541-119163051 (+) GRCh38

MGI Vertebrate Homology

Srrm4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRRM4
Gene Tree

Srrm4

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Phenotype Summary

44 phenotypes from 4 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
7 images
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

10
Radiation induced

1
Spontaneous

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Srrm4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most homozygous null mice die neonatally with respiratory defects while survivors show tremors, head tilt, circling, premature neurogenesis, altered neurite outgrowth, cortical layering and axon guidance. Homozygotes for a spontaneous deletion show inner ear hair cell, balance and hearing defects.

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All GO Annotations

19
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

25
cDNA Data

6
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srrm4

ZFIN srrm4

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All Sequences

47
RefSeq

6
UniProt

4
CCDS

CCDS19601.1

Ensembl

ENSMUSG00000063919 (Evidence)
NCBI Gene

68955

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063919	Ensembl Gene Model \| MGI Sequence Detail	152543	C57BL/6J	± kb
transcript	ENSMUST00000076124	Ensembl \| MGI Sequence Detail	7472	Not Applicable
polypeptide	ENSMUSP00000075488	Ensembl \| MGI Sequence Detail	608	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030470 serine/arginine repetitive matrix protein 4

(term hierarchy)
InterPro Domains

IPR052109 Serine/Arginine Repetitive Matrix Domain-Containing Protein

IPR029360 Serine/arginine repetitive matrix protein, C-terminal

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All nucleic 16

cDNA 9

Primer pair 4

Other 3

Microarray probesets 2

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MGD-MRK-1687, MGD-MRK-9868, MGI:1925852, MGI:88220

Summaries

All 74

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 44
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srrm4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52870	Chr5:116729917-116729924 (-)	-45 bp
Tssr52869	Chr5:116729870-116729889 (-)	-4 bp
Tssr52868	Chr5:116729841-116729852 (-)	29 bp
Tssr52867	Chr5:116729531-116729542 (-)	339 bp
Tssr52866	Chr5:116683909-116683939 (-)	45,952 bp
Tssr52865	Chr5:116683104-116683114 (-)	46,767 bp
Tssr52864	Chr5:116584766-116584799 (-)	145,093 bp
Tssr52863	Chr5:116579344-116579355 (-)	150,526 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24