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Slc35c1 Gene Detail
Summary
  • Symbol
    Slc35c1
  • Name
    solute carrier family 35, member C1
  • Synonyms
    E430007K15Rik, FUCT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443301
    NCBI Gene: 228368
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92283109-92290863 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443301
 protein coding gene Chr2:92283109-92290883 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026169
 protein coding gene Chr2:93883149-93890936 (-)
A/J MGP_AJ_G0026130
 protein coding gene Chr2:90086353-90094138 (-)
AKR/J MGP_AKRJ_G0026111
 protein coding gene Chr2:92579850-92587622 (-)
BALB/cJ MGP_BALBcJ_G0026139
 protein coding gene Chr2:90271992-90279761 (-)
C3H/HeJ MGP_C3HHeJ_G0025890
 protein coding gene Chr2:92881282-92889409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026590
 protein coding gene Chr2:97103272-97111055 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023981
 protein coding gene Chr2:86580029-86587785 (-)
CAST/EiJ MGP_CASTEiJ_G0025355
 protein coding gene Chr2:93413299-93440486 (-)
CBA/J MGP_CBAJ_G0025868
 protein coding gene Chr2:100484728-100492284 (-)
DBA/2J MGP_DBA2J_G0026004
 protein coding gene Chr2:89679548-89687317 (-)
FVB/NJ MGP_FVBNJ_G0025967
 protein coding gene Chr2:88792042-88799882 (-)
LP/J MGP_LPJ_G0026108
 protein coding gene Chr2:94083597-94091387 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025993
 protein coding gene Chr2:103447103-103454890 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026644
 protein coding gene Chr2:92665887-92673665 (-)
PWK/PhJ MGP_PWKPhJ_G0025090
 protein coding gene Chr2:89418520-89433713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024891
 protein coding gene Chr2:92218044-92238356 (-)
WSB/EiJ MGP_WSBEiJ_G0025422
 protein coding gene Chr2:93284983-93292750 (-)



Homology
more
  • Human Ortholog
    SLC35C1, solute carrier family 35 member C1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC35C1, solute carrier family 35 member C1
  • Synonyms
    CDG2C, FUCT1
  • Links
    NCBI Gene ID: 55343
    neXtProt AC: NX_Q96A29
    UniProt: Q96A29

  • Chr Location
    11p11.2
Human Diseases
more
  • Diseases
    1 with Slc35c1 mouse models; 1 with human SLC35C1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial perinatal and postnatal lethality, growth retardation, reduced fertility, leukocytosis, defective lung and primary lymph node development and altered lymphocyte rolling and adhesion. Mortality is increased on an inbred background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    96
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228368 NCBI Gene Model | MGI Sequence Detail 7755 C57BL/6J ±  kb
    transcript NM_211358 RefSeq | MGI Sequence Detail 3154 C57BL/6  
    polypeptide Q8BLX4 UniProt | EBI | MGI Sequence Detail 363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354047 Lu L, et al., In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2. J Biol Chem. 2023 Dec;299(12):105406
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory