Olfm2 MGI Mouse Gene Detail - MGI:3045350

Symbol

Olfm2
Name

olfactomedin 2
Synonyms

A030009A06Rik

Feature Type

protein coding gene
IDs

MGI:3045350
NCBI Gene: 244723
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:20578986-20657645 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.60 cM
Mapping Data

1 experiment

SNPs within 2kb

1997 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045350	protein coding gene	Chr9:20578986-20657660 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034425	protein coding gene	Chr9:17815692-17878490 (-)
A/J	MGP_AJ_G0034403	protein coding gene	Chr9:17531173-17594260 (-)
AKR/J	MGP_AKRJ_G0034330	protein coding gene	Chr9:17851550-17912325 (-)
BALB/cJ	MGP_BALBcJ_G0034394	protein coding gene	Chr9:17435001-17495881 (-)
C3H/HeJ	MGP_C3HHeJ_G0034106	protein coding gene	Chr9:18161701-18228062 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034915	protein coding gene	Chr9:18546039-18608391 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031845	protein coding gene	Chr9:16666863-16726555 (-)
CAST/EiJ	MGP_CASTEiJ_G0033429	protein coding gene	Chr9:17976605-18040866 (-)
CBA/J	MGP_CBAJ_G0034079	protein coding gene	Chr9:19249401-19317932 (-)
DBA/2J	MGP_DBA2J_G0034238	protein coding gene	Chr9:17526966-17588701 (-)
FVB/NJ	MGP_FVBNJ_G0034181	protein coding gene	Chr9:17027246-17088557 (-)
LP/J	MGP_LPJ_G0034323	protein coding gene	Chr9:17999128-18064034 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034224	protein coding gene	Chr9:20887087-20948826 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034935	protein coding gene	Chr9:17795131-17864295 (-)
PWK/PhJ	MGP_PWKPhJ_G0033135	protein coding gene	Chr9:17488638-17550935 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032969	protein coding gene	Chr9:17837787-17900109 (-)
WSB/EiJ	MGP_WSBEiJ_G0033544	protein coding gene	Chr9:17526829-17593089 (-)

Human Ortholog

OLFM2, olfactomedin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OLFM2, olfactomedin 2
Synonyms

NOE2, NOELIN2, NOELIN2_V1, OlfC
Links

HGNC:17189

NCBI Gene ID: 93145

neXtProt AC: NX_O95897

UniProt: O95897
Chr Location

19p13.2; chr19:9853718-9936515 (-) GRCh38

MGI Vertebrate Homology

Olfm2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OLFM2
Gene Tree

Olfm2

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit moderate locomotor and anxiety-related behavioral abnormalities, altered visual evoked potential, and reduced compactness of myelin sheaths in the optic nerve.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

37
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase olfm2

ZFIN olfm2a

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All Sequences

47
RefSeq

12
UniProt

3
CCDS

CCDS40546.1, CCDS90507.1, CCDS90508.1

Ensembl

ENSMUSG00000032172 (Evidence)
NCBI Gene

244723

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032172	Ensembl Gene Model \| MGI Sequence Detail	78660	C57BL/6J	± kb
transcript	ENSMUST00000217198	Ensembl \| MGI Sequence Detail	2005	Not Applicable
polypeptide	ENSMUSP00000151018	Ensembl \| MGI Sequence Detail	478	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011624 noelin-2

(term hierarchy)
InterPro Domains

IPR022082 Noelin domain

IPR003112 Olfactomedin-like domain

IPR050605 Olfactomedin-like domain-containing protein
GlyGen

Q8BM13 10 sites, 6 N-linked glycans (6 sites), 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 11

Primer pair 3

Microarray probesets 2

Summaries

All 33

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:341089 Boudkkazi S, et al., A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors. Neuron. 2023 Aug 16;111(16):2544-2556.e9

TSS for Olfm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88331	Chr9:20657680-20657697 (-)	-44 bp
Tssr88330	Chr9:20657643-20657664 (-)	-9 bp
Tssr88329	Chr9:20657614-20657635 (-)	20 bp
Tssr88328	Chr9:20657558-20657576 (-)	78 bp
Tssr88327	Chr9:20657529-20657547 (-)	107 bp
Tssr88326	Chr9:20638292-20638308 (-)	19,345 bp
Tssr88325	Chr9:20638261-20638280 (-)	19,374 bp
Tssr88324	Chr9:20579340-20579392 (-)	78,279 bp
Tssr88323	Chr9:20579295-20579310 (-)	78,342 bp
Tssr88322	Chr9:20579220-20579292 (-)	78,389 bp
Tssr88321	Chr9:20579149-20579215 (-)	78,463 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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