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Atrip Gene Detail
Summary
  • Symbol
    Atrip
  • Name
    ATR interacting protein
  • Synonyms
    6620401K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925349
    NCBI Gene: 235610
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:108888815-108903192 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.63 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    502 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925349
 protein coding gene Chr9:108887001-108903192 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035324
 protein coding gene Chr9:111016563-111032276 (-)
A/J MGP_AJ_G0035303
 protein coding gene Chr9:106932851-106947243 (-)
AKR/J MGP_AKRJ_G0035235
 protein coding gene Chr9:109626368-109640760 (-)
BALB/cJ MGP_BALBcJ_G0035297
 protein coding gene Chr9:106632956-106647348 (-)
C3H/HeJ MGP_C3HHeJ_G0035007
 protein coding gene Chr9:110016039-110030944 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035817
 protein coding gene Chr9:114043105-114057428 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032715
 protein coding gene Chr9:104339340-104354142 (-)
CAST/EiJ MGP_CASTEiJ_G0034318
 protein coding gene Chr9:109989652-110003991 (-)
CBA/J MGP_CBAJ_G0034975
 protein coding gene Chr9:118056006-118072391 (-)
DBA/2J MGP_DBA2J_G0035136
 protein coding gene Chr9:106388078-106403094 (-)
FVB/NJ MGP_FVBNJ_G0035084
 protein coding gene Chr9:105208049-105222578 (-)
LP/J MGP_LPJ_G0035212
 protein coding gene Chr9:111202220-111216545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035123
 protein coding gene Chr9:119610036-119624414 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035838
 protein coding gene Chr9:109895802-109910173 (-)
PWK/PhJ MGP_PWKPhJ_G0034025
 protein coding gene Chr9:106724667-106739827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033860
 protein coding gene Chr9:109960915-109975709 (-)
WSB/EiJ MGP_WSBEiJ_G0034439
 protein coding gene Chr9:109793153-109808987 (-)



Homology
more
  • Human Ortholog
    ATRIP, ATR interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATRIP, ATR interacting protein
  • Links
    NCBI Gene ID: 84126
    neXtProt AC: NX_Q8WXE1
    UniProt: Q8WXE1

  • Chr Location
    3p21.31; chr3:48446710-48467645 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Atrip mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Neuron-specific homozygous knockout affects brain and eye development and leads to death around nine days after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    35
  • cDNA Data
    37
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 235610 NCBI Gene Model | MGI Sequence Detail 14378 C57BL/6J ±  kb
    transcript NM_172774 RefSeq | MGI Sequence Detail 2572 C57BL/6  
    polypeptide Q8BMG1 UniProt | EBI | MGI Sequence Detail 785 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory