Eif1ax Gene Detail

Summary

• Symbol
  Eif1ax
• Name
  eukaryotic translation initiation factor 1A, X-linked
• Synonyms
  1500010B24Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1913485
  NCBI Gene: 66235
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  ChrX:158155174-158172617 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 73.41 cM, cytoband F4
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  482 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913485	protein coding gene	ChrX:158155174-158172924 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036224	protein coding gene	ChrX:157266759-157285633 (+)
A/J	MGP_AJ_G0036194	protein coding gene	ChrX:156553842-156571904 (+)
AKR/J	MGP_AKRJ_G0036122	protein coding gene	ChrX:161519539-161541101 (+)
BALB/cJ	MGP_BALBcJ_G0036187	protein coding gene	ChrX:154627288-154647175 (+)
C3H/HeJ	MGP_C3HHeJ_G0035893	protein coding gene	ChrX:157661129-157679811 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036709	protein coding gene	ChrX:161954892-161975404 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033531	protein coding gene	ChrX:147835710-147853377 (+)
CAST/EiJ	MGP_CASTEiJ_G0035182	protein coding gene	ChrX:136702373-136723654 (+)
CBA/J	MGP_CBAJ_G0035868	protein coding gene	ChrX:166565846-166583738 (+)
DBA/2J	MGP_DBA2J_G0036034	protein coding gene	ChrX:155535837-155556957 (+)
FVB/NJ	MGP_FVBNJ_G0035965	protein coding gene	ChrX:154657456-154675162 (+)
LP/J	MGP_LPJ_G0036119	protein coding gene	ChrX:158433315-158451596 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035997	protein coding gene	ChrX:175261297-175280284 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036750	protein coding gene	ChrX:156812262-156832998 (+)
PWK/PhJ	MGP_PWKPhJ_G0034880	protein coding gene	ChrX:133586532-133604858 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034701	protein coding gene	ChrX:137129813-137147787 (+)
WSB/EiJ	MGP_WSBEiJ_G0035317	protein coding gene	ChrX:154779249-154796906 (+)

Homology

• Human Ortholog
  EIF1AX, eukaryotic translation initiation factor 1A X-linked

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  EIF1AX, eukaryotic translation initiation factor 1A X-linked
  
• Synonyms
  eIF-1A, EIF1A, EIF1AP1, eIF-4C, EIF4C
• Links
  HGNC:3250

  NCBI Gene ID: 1964

  neXtProt AC: NX_P47813

  UniProt: P47813

  
  
• Chr Location
  Xp22.12; chrX:20124525-20141838 (-)  GRCh38

---

• Human Ortholog
  EIF1AY, eukaryotic translation initiation factor 1A Y-linked
  
• Synonyms
  eIF-4C
• Links
  HGNC:3252

  NCBI Gene ID: 9086

  neXtProt AC: NX_O14602

  UniProt: O14602

  
  
• Chr Location
  Yq11.223; chrY:20575776-20593154 (+)  GRCh38

---

• MGI Vertebrate Homology
  Eif1ax stringent orthology
  2 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: EIF1AX, EIF1AY
• Gene Tree
  Eif1ax
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  17
• Endonuclease-mediated
  2
• Gene trapped
  12
• Radiation induced
  1
• Spontaneous
  1
• Targeted
  1
• Genomic Mutations
  2 involving Eif1ax
• Find Mice (IMSR)
  13 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  6

Expression

• Assay Results
  710
• Tissues
  3
• cDNA Data
  25
• Literature Summary
  3

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase eif1ax

Sequences &
Gene Models

• All Sequences
  61
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS41192.1

• Ensembl
  ENSMUSG00000067194 (Evidence)
• NCBI Gene
  66235

Representative Sequences			Length	Strain/Species
genomic	66235	NCBI Gene Model | MGI Sequence Detail	17444	C57BL/6J
transcript	NM_025437	RefSeq | MGI Sequence Detail	4865	C57BL/6
polypeptide	Q8BMJ3	UniProt | EBI | MGI Sequence Detail	144	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR012340 Nucleic acid-binding, OB-fold
  IPR006196 RNA-binding domain, S1, IF1 type
  IPR001253 Translation initiation factor 1A (eIF-1A)
  IPR018104 Translation initiation factor 1A (eIF-1A), conserved site

Molecular
Reagents

• All nucleic 26

  cDNA 25

  Primer pair 1

  
  

  Microarray probesets 9

Other
Accession IDs

MGI:2147882

References

• Summaries
  All 38

  Developmental Gene Expression 3

  Gene Ontology 6

  Phenotypes 9
• Earliest
  J:46359 Blair HJ, et al., Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. Hum Mol Genet. 1998 Mar;7(3):549-55
• Latest
  J:313842 Mattebo A, et al., Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity. Sci Rep. 2021 Aug 5;11(1):15898

TSS for Eif1ax:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162477	ChrX:158154975-158155014 (+)	-179 bp
Tssr162478	ChrX:158155171-158155286 (+)	55 bp
Tssr162479	ChrX:158155287-158155296 (+)	118 bp
Tssr162480	ChrX:158155301-158155312 (+)	133 bp