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Chrnb3 Gene Detail
Summary
  • Symbol
    Chrnb3
  • Name
    cholinergic receptor, nicotinic, beta polypeptide 3
  • Synonyms
    5730417K16Rik, Acrb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106212
    NCBI Gene: 108043
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27858739-27889758 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 16.00 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1172 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106212
 protein coding gene Chr8:27858688-27889758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033508
 protein coding gene Chr8:25580785-25611123 (+)
A/J MGP_AJ_G0033487
 protein coding gene Chr8:24612491-24641779 (+)
AKR/J MGP_AKRJ_G0033412
 protein coding gene Chr8:25451097-25479973 (+)
BALB/cJ MGP_BALBcJ_G0033483
 protein coding gene Chr8:24754574-24783687 (+)
C3H/HeJ MGP_C3HHeJ_G0033197
 protein coding gene Chr8:25647726-25676780 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034000
 protein coding gene Chr8:26609081-26640934 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030950
 protein coding gene Chr8:21817905-21851958 (+)
CAST/EiJ MGP_CASTEiJ_G0032523
 protein coding gene Chr8:25152183-25184347 (+)
CBA/J MGP_CBAJ_G0033173
 protein coding gene Chr8:27640383-27670165 (+)
DBA/2J MGP_DBA2J_G0033327
 protein coding gene Chr8:24619201-24646774 (+)
FVB/NJ MGP_FVBNJ_G0033271
 protein coding gene Chr8:24382225-24411732 (+)
LP/J MGP_LPJ_G0033417
 protein coding gene Chr8:25534436-25565130 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033314
 protein coding gene Chr8:27081947-27111592 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034019
 protein coding gene Chr8:25401448-25430999 (+)
PWK/PhJ MGP_PWKPhJ_G0032235
 protein coding gene Chr8:24202480-24235809 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032068
 protein coding gene Chr8:24728189-24760760 (+)
WSB/EiJ MGP_WSBEiJ_G0032639
 protein coding gene Chr8:25583323-25620039 (+)



Homology
more
  • Human Ortholog
    CHRNB3, cholinergic receptor nicotinic beta 3 subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNB3, cholinergic receptor nicotinic beta 3 subunit
  • Links
    NCBI Gene ID: 1142
    neXtProt AC: NX_Q05901
    UniProt: Q05901

  • Chr Location
    8p11.21; chr8:42697366-42737407 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human CHRNB3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display hyperactivity and reflex abnormalities but were otherwise phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    43
  • cDNA Data
    9
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031492 Ensembl Gene Model | MGI Sequence Detail 31020 C57BL/6J ±  kb
transcript ENSMUST00000060943 Ensembl | MGI Sequence Detail 4589 Not Applicable  
polypeptide ENSMUSP00000052297 Ensembl | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005464 neuronal acetylcholine receptor subunit beta-3
    (term hierarchy)
  • InterPro Domains
    IPR038050 Neuronal acetylcholine receptor
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    IPR002394 Nicotinic acetylcholine receptor
  • GlyGen
    Q8BMN3 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-33904, MGI:1917785
References
more
  • Summaries
    All 52
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:31397 Drescher DG, et al., Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Nov;112(3):267-73
  • Latest
    J:289269 Jackson AB, et al., The beta3 subunit of the nicotinic acetylcholine receptor is required for nicotine withdrawal-induced affective but not physical signs or nicotine reward in mice. Pharmacol Biochem Behav. 2019 Aug;183:1-5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory