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Spon2 Gene Detail
Summary
  • Symbol
    Spon2
  • Name
    spondin 2, extracellular matrix protein
  • Synonyms
    2310045I24Rik, Mindin, M-spondin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923724
    NCBI Gene: 100689
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33370862-33375596 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923724
 protein coding gene Chr5:33355528-33375799 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029442
 protein coding gene Chr5:31365006-31387183 (-)
A/J MGP_AJ_G0029409
 protein coding gene Chr5:30340650-30362182 (-)
AKR/J MGP_AKRJ_G0029358
 protein coding gene Chr5:31523000-31543232 (-)
BALB/cJ MGP_BALBcJ_G0029419
 protein coding gene Chr5:30869223-30889425 (-)
C3H/HeJ MGP_C3HHeJ_G0029141
 protein coding gene Chr5:31551908-31572141 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029873
 protein coding gene Chr5:33244264-33269521 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027110
 protein coding gene Chr5:28143310-28164100 (-)
CAST/EiJ MGP_CASTEiJ_G0028550
 protein coding gene Chr5:30634570-30656652 (-)
CBA/J MGP_CBAJ_G0029109
 protein coding gene Chr5:33935952-33958417 (-)
DBA/2J MGP_DBA2J_G0029257
 protein coding gene Chr5:30524155-30545180 (-)
FVB/NJ MGP_FVBNJ_G0029216
 protein coding gene Chr5:29938059-29958219 (-)
LP/J MGP_LPJ_G0029342
 protein coding gene Chr5:31778117-31798232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029246
 protein coding gene Chr5:34802180-34822451 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029906
 protein coding gene Chr5:31032369-31052563 (-)
PWK/PhJ MGP_PWKPhJ_G0028275
 protein coding gene Chr5:29650127-29670921 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028106
 protein coding gene Chr5:30486638-30506744 (-)
WSB/EiJ MGP_WSBEiJ_G0028631
 protein coding gene Chr5:31085479-31105665 (-)



Homology
more
  • Human Ortholog
    SPON2, spondin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPON2, spondin 2
  • Synonyms
    DIL-1, DIL1, MINDIN, M-SPONDIN
  • Links
    NCBI Gene ID: 10417
    neXtProt AC: NX_Q9BUD6
    UniProt: Q9BUD6

  • Chr Location
    4p16.3; chr4:1166932-1208962 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    6
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Spon2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    25 strains or lines available
Mice homozygous for disruptions in this gene have an essentially normal phenotype. There is some alteration in succeptibility to bacterial infection however.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    37
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100689 NCBI Gene Model | MGI Sequence Detail 4735 C57BL/6J ±  kb
transcript NM_133903 RefSeq | MGI Sequence Detail 2237 C57BL/6  
polypeptide Q8BMS2 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140924
References
more
  • Summaries
    All 63
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 36
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:329299 Badarinath K, et al., Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. Cell Rep. 2022 Sep 20;40(12):111390
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory