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Fat3 Gene Detail
Summary
  • Symbol
    Fat3
  • Name
    FAT atypical cadherin 3
  • Synonyms
    9430076A06Rik, D430038H04Rik, LOC234973, LOC382129
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444314
    NCBI Gene: 270120
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:15821485-16412581 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 5.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17484 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444314
 protein coding gene Chr9:15821485-16413981 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034370
 protein coding gene Chr9:12921700-13401397 (-)
A/J MGP_AJ_G0034348
 protein coding gene Chr9:12848722-13319183 (-)
AKR/J MGP_AKRJ_G0034276
 protein coding gene Chr9:12874811-13353866 (-)
BALB/cJ MGP_BALBcJ_G0034342
 protein coding gene Chr9:12618550-13085893 (-)
C3H/HeJ MGP_C3HHeJ_G0034053
 protein coding gene Chr9:13183879-13658854 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034864
 protein coding gene Chr9:13336683-13824698 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031802
 protein coding gene Chr9:12084325-12550884 (-)
CAST/EiJ MGP_CASTEiJ_G0033380
 protein coding gene Chr9:13044689-13528066 (-)
CBA/J MGP_CBAJ_G0034026
 protein coding gene Chr9:13962435-14461730 (-)
DBA/2J MGP_DBA2J_G0034183
 protein coding gene Chr9:12697260-13159585 (-)
FVB/NJ MGP_FVBNJ_G0034128
 protein coding gene Chr9:12281307-12750256 (-)
LP/J MGP_LPJ_G0034269
 protein coding gene Chr9:13047373-13561557 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034172
 protein coding gene Chr9:14960371-15441580 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034883
 protein coding gene Chr9:12918160-13397207 (-)
PWK/PhJ MGP_PWKPhJ_G0033086
 protein coding gene Chr9:12792253-13266444 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032921
 protein coding gene Chr9:13022117-13511460 (-)
WSB/EiJ MGP_WSBEiJ_G0033496
 protein coding gene Chr9:12749519-13232159 (-)



Homology
more
  • Human Ortholog
    FAT3, FAT atypical cadherin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAT3, FAT atypical cadherin 3
  • Synonyms
    CDHF15, CDHR10, hFat3
  • Links
    NCBI Gene ID: 120114
    neXtProt AC: NX_Q8TDW7
    UniProt: Q8TDW7

  • Chr Location
    11q14.3; chr11:92224818-92896473 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozgyous for a knock-out allele exhibit abnormal amacrine cell differentiation and migration that result in the formation of two additional plexiform layers and thickened retinal ganglion layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1193
  • Tissues
    133
  • cDNA Data
    48
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074505 Ensembl Gene Model | MGI Sequence Detail 591097 C57BL/6J ±  kb
    transcript ENSMUST00000217308 Ensembl | MGI Sequence Detail 18760 Not Applicable  
    polypeptide ENSMUSP00000148968 Ensembl | MGI Sequence Detail 4555 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 48
      Primer pair 5
      Other 1

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGI:2685356, MGI:2685978, MGI:3036241
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 14
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:353281 Rybiczka-Tesulov M, et al., Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nat Commun. 2024 Aug 8;15(1):6773
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory