Sfr1 MGI Mouse Gene Detail - MGI:1915038 - SWI5 dependent recombination repair 1

Symbol

Sfr1
Name

SWI5 dependent recombination repair 1
Synonyms

6330577E15Rik

Feature Type

protein coding gene
IDs

MGI:1915038
NCBI Gene: 67788
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:47720159-47724027 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 40.41 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

209 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915038	protein coding gene	Chr19:47720121-47724027 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025233	protein coding gene	Chr19:47565164-47570714 (+)
A/J	MGP_AJ_G0025209	protein coding gene	Chr19:45176305-45180082 (+)
AKR/J	MGP_AKRJ_G0025178	protein coding gene	Chr19:46656891-46660676 (+)
BALB/cJ	MGP_BALBcJ_G0025204	protein coding gene	Chr19:45238146-45242107 (+)
C3H/HeJ	MGP_C3HHeJ_G0024964	protein coding gene	Chr19:46831550-46835304 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025647	protein coding gene	Chr19:48690633-48694465 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023060	protein coding gene	Chr19:44406994-44410771 (+)
CAST/EiJ	MGP_CASTEiJ_G0024429	protein coding gene	Chr19:46659664-46665971 (+)
CBA/J	MGP_CBAJ_G0024944	protein coding gene	Chr19:51148358-51152076 (+)
DBA/2J	MGP_DBA2J_G0025076	protein coding gene	Chr19:44997116-45000836 (+)
FVB/NJ	MGP_FVBNJ_G0025037	protein coding gene	Chr19:44785486-44789263 (+)
LP/J	MGP_LPJ_G0025162	protein coding gene	Chr19:47446084-47450868 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025068	protein coding gene	Chr19:50399214-50404021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025705	protein coding gene	Chr19:46764486-46769138 (+)
PWK/PhJ	MGP_PWKPhJ_G0024178	protein coding gene	Chr19:44961684-44965755 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023981	protein coding gene	Chr19:45434959-45438795 (+)
WSB/EiJ	MGP_WSBEiJ_G0024499	protein coding gene	Chr19:46929578-46934323 (+)

Human Ortholog

SFR1, SWI5 dependent homologous recombination repair protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFR1, SWI5 dependent homologous recombination repair protein 1
Synonyms

bA373N18.1, C10orf78, MEI5, MEIR5
Links

HGNC:29574

NCBI Gene ID: 119392

neXtProt AC: NX_Q86XK3

UniProt: Q86XK3
Chr Location

10q25.1; chr10:104120166-104126385 (+) GRCh38

MGI Vertebrate Homology

Sfr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFR1
Gene Tree

Sfr1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

3
cDNA Data

149
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sfr1

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All Sequences

48
RefSeq

4
UniProt

2
CCDS

CCDS38019.1

Ensembl

ENSMUSG00000025066 (Evidence)
NCBI Gene

67788

			Length	Strain/Species	Flank
genomic	67788	NCBI Gene Model \| MGI Sequence Detail	3869	C57BL/6J	± kb
transcript	NM_026377	RefSeq \| MGI Sequence Detail	1583	C57BL/6
polypeptide	Q8BP27	UniProt \| EBI \| MGI Sequence Detail	319	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031230 Swi5-dependent recombination DNA repair protein 1 homolog

(term hierarchy)
InterPro Domains

IPR018468 SFR1/Mei5 family

IPR042429 Swi5-dependent recombination DNA repair protein 1 homolog

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All nucleic 149

cDNA 149

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sfr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156884	Chr19:47720182-47720207 (+)	36 bp
Tssr156885	Chr19:47720213-47720236 (+)	66 bp
Tssr156886	Chr19:47721384-47721389 (+)	1,228 bp
Tssr156887	Chr19:47722091-47722104 (+)	1,939 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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