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Slc15a3 Gene Detail
Summary
  • Symbol
    Slc15a3
  • Name
    solute carrier family 15, member 3
  • Synonyms
    cI-1, Ci1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929691
    NCBI Gene: 65221
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10819908-10835279 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 7.23 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    473 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929691
 protein coding gene Chr19:10817091-10836726 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024858
 protein coding gene Chr19:8213491-8234260 (+)
A/J MGP_AJ_G0024826
 protein coding gene Chr19:7656599-7676252 (+)
AKR/J MGP_AKRJ_G0024801
 protein coding gene Chr19:7956392-7975950 (+)
BALB/cJ MGP_BALBcJ_G0024826
 protein coding gene Chr19:7701644-7721241 (+)
C3H/HeJ MGP_C3HHeJ_G0024592
 protein coding gene Chr19:7845730-7865220 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025274
 protein coding gene Chr19:8564532-8587122 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022701
 protein coding gene Chr19:8073328-8092910 (+)
CAST/EiJ MGP_CASTEiJ_G0024065
 protein coding gene Chr19:7495034-7518426 (+)
CBA/J MGP_CBAJ_G0024566
 protein coding gene Chr19:8614320-8636669 (+)
DBA/2J MGP_DBA2J_G0024693
 protein coding gene Chr19:7661384-7680801 (+)
FVB/NJ MGP_FVBNJ_G0024660
 protein coding gene Chr19:7706054-7725983 (+)
LP/J MGP_LPJ_G0024780
 protein coding gene Chr19:8165681-8185370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024687
 protein coding gene Chr19:8514185-8534983 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025322
 protein coding gene Chr19:7976540-7998747 (+)
PWK/PhJ MGP_PWKPhJ_G0023810
 protein coding gene Chr19:7114805-7134716 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023615
 protein coding gene Chr19:7160004-7180422 (+)
WSB/EiJ MGP_WSBEiJ_G0024127
 protein coding gene Chr19:7867071-7886395 (+)



Homology
more
  • Human Ortholog
    SLC15A3, solute carrier family 15 member 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC15A3, solute carrier family 15 member 3
  • Synonyms
    hPHT2, OCTP, PHT2, PTR3
  • Links
    NCBI Gene ID: 51296
    neXtProt AC: NX_Q8IY34
    UniProt: Q8IY34

  • Chr Location
    11q12.2; chr11:60937060-60952653 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene is involved in pathogen sensing by dendritic cells. Homozygous KO results in a reduction of the number of these cells displaying tubular endo-lysosomes after LPS treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    10
  • cDNA Data
    5
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65221 NCBI Gene Model | MGI Sequence Detail 15372 C57BL/6J ±  kb
    transcript NM_023044 RefSeq | MGI Sequence Detail 2345 C57BL/6  
    polypeptide Q8BPX9 UniProt | EBI | MGI Sequence Detail 578 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014942 solute carrier family 15 member 3
      (term hierarchy)
    • InterPro Domains
      IPR036259 MFS transporter superfamily
      IPR000109 Proton-dependent oligopeptide transporter family
      IPR018456 PTR2 family proton/oligopeptide symporter, conserved site
    • GlyGen
      Q8BPX9 3 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory