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Ppfia2 Gene Detail
Summary
  • Symbol
    Ppfia2
  • Name
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
  • Synonyms
    E130120L08Rik, Liprin-alpha2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443834
    NCBI Gene: 327814
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:106305129-106769329 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 55.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15887 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443834
 protein coding gene Chr10:106305129-106771813 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017705
 protein coding gene Chr10:108568888-109081788 (+)
A/J MGP_AJ_G0017682
 protein coding gene Chr10:104542845-105017921 (+)
AKR/J MGP_AKRJ_G0017644
 protein coding gene Chr10:107608767-108080179 (+)
BALB/cJ MGP_BALBcJ_G0017646
 protein coding gene Chr10:104931365-105400913 (+)
C3H/HeJ MGP_C3HHeJ_G0017471
 protein coding gene Chr10:107677131-108160889 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018103
 protein coding gene Chr10:112378153-112881868 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015782
 protein coding gene Chr10:99509209-99969719 (+)
CAST/EiJ MGP_CASTEiJ_G0017032
 protein coding gene Chr10:107749680-108257073 (+)
CBA/J MGP_CBAJ_G0017440
 protein coding gene Chr10:116733068-117255525 (+)
DBA/2J MGP_DBA2J_G0017545
 protein coding gene Chr10:103679357-104154094 (+)
FVB/NJ MGP_FVBNJ_G0017539
 protein coding gene Chr10:102702902-103172856 (+)
LP/J MGP_LPJ_G0017619
 protein coding gene Chr10:109233580-109712982 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017569
 protein coding gene Chr10:119084972-119726915 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018141
 protein coding gene Chr10:107567649-108050208 (+)
PWK/PhJ MGP_PWKPhJ_G0016814
 protein coding gene Chr10:103718658-104216299 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016604
 protein coding gene Chr10:106327766-106804250 (+)
WSB/EiJ MGP_WSBEiJ_G0017092
 protein coding gene Chr10:107666136-108164160 (+)



Homology
more
  • Human Ortholog
    PPFIA2, PTPRF interacting protein alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPFIA2, PTPRF interacting protein alpha 2
  • Links
    NCBI Gene ID: 8499
    neXtProt AC: NX_O75334
    UniProt: O75334

  • Chr Location
    12q21.31; chr12:81257975-81759553 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    41
  • cDNA Data
    31
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 327814 NCBI Gene Model | MGI Sequence Detail 464201 C57BL/6J ±  kb
    transcript NM_001359672 RefSeq | MGI Sequence Detail 6463 C57BL/6  
    polypeptide Q8BSS9 UniProt | EBI | MGI Sequence Detail 1257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013069 liprin-alpha-2
      (term hierarchy)
    • InterPro Domains
      IPR029515 LAR-interacting protein, Liprin
      IPR037620 Liprin-alpha, SAM domain repeat 1
      IPR037621 Liprin-alpha, SAM domain repeat 2
      IPR037622 Liprin-alpha, SAM domain repeat 3
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    • GlyGen
      Q8BSS9 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 2
      cDNA 31
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2445215
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:358058 Emperador-Melero J, et al., Distinct active zone protein machineries mediate Ca(2+) channel clustering and vesicle priming at hippocampal synapses. Nat Neurosci. 2024 Sep;27(9):1680-1694
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory