Cxcl16 MGI Mouse Gene Detail - MGI:1932682 - C-X-C motif chemokine ligand 16

Symbol

Cxcl16
Name

C-X-C motif chemokine ligand 16
Synonyms

0910001K24Rik, Scavenger Receptor, SR-PSOX, SR-PSOX/CXCL16

Feature Type

protein coding gene
IDs

MGI:1932682
NCBI Gene: 66102
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr11:70345215-70350810 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

57 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932682	protein coding gene	Chr11:70344809-70350810 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018596	protein coding gene	Chr11:70988059-70994141 (-)
A/J	MGP_AJ_G0018564	protein coding gene	Chr11:68294231-68299834 (-)
AKR/J	MGP_AKRJ_G0018533	protein coding gene	Chr11:70342993-70350022 (-)
BALB/cJ	MGP_BALBcJ_G0018536	protein coding gene	Chr11:68613571-68619185 (-)
C3H/HeJ	MGP_C3HHeJ_G0018349	protein coding gene	Chr11:70365166-70371946 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018987	protein coding gene	Chr11:73127907-73133642 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016632	protein coding gene	Chr11:65219714-65226365 (-)
CAST/EiJ	MGP_CASTEiJ_G0017904	protein coding gene	Chr11:70621736-70627397 (-)
CBA/J	MGP_CBAJ_G0018321	protein coding gene	Chr11:76403453-76409104 (-)
DBA/2J	MGP_DBA2J_G0018431	protein coding gene	Chr11:67877918-67883912 (-)
FVB/NJ	MGP_FVBNJ_G0018421	protein coding gene	Chr11:67522408-67528446 (-)
LP/J	MGP_LPJ_G0018501	protein coding gene	Chr11:71559069-71564692 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018444	protein coding gene	Chr11:76989778-76996995 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019029	protein coding gene	Chr11:70607389-70613130 (-)
PWK/PhJ	MGP_PWKPhJ_G0017678	protein coding gene	Chr11:68516637-68522863 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017468	protein coding gene	Chr11:70414071-70421078 (-)
WSB/EiJ	MGP_WSBEiJ_G0017958	protein coding gene	Chr11:70267737-70273294 (-)

Human Ortholog

CXCL16, C-X-C motif chemokine ligand 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCL16, C-X-C motif chemokine ligand 16
Synonyms

CXCLG16, SR-PSOX, SRPSOX
Links

HGNC:16642

NCBI Gene ID: 58191

neXtProt AC: NX_Q9H2A7

UniProt: Q9H2A7
Chr Location

17p13.2; chr17:4733533-4739928 (-) GRCh38

MGI Vertebrate Homology

Cxcl16 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CXCL16
Gene Tree

Cxcl16

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

8
Targeted

5
Genomic Mutations

3 involving Cxcl16
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased NK T cells, decreased secretion and serum levels of IL4 and IFN-gamma, and decreased inhibition of B16 melanoma cell growth by alpha-galactosylceramide treatment.

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All GO Annotations

28
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

22
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

5
UniProt

4
CCDS

CCDS24948.1

Ensembl

ENSMUSG00000018920 (Evidence)
NCBI Gene

66102

			Length	Strain/Species	Flank
genomic	66102	NCBI Gene Model \| MGI Sequence Detail	5596	C57BL/6J	± kb
transcript	NR_151497	RefSeq \| MGI Sequence Detail	1692	C57BL/6
polypeptide	Q8BSU2	UniProt \| EBI \| MGI Sequence Detail	246	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001804 C-X-C motif chemokine 16

(term hierarchy)
InterPro Domains

IPR026296 CXC chemokine 16

IPR048585 C-X-C motif chemokine 16 domain

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 4

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MGI:1913352, MGI:2144468, MGI:2144594

Summaries

All 74

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:349428 Srivastava N, et al., CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity. Immunity. 2024 May 6;

TSS for Cxcl16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108974	Chr11:70350832-70350839 (-)	-26 bp
Tssr108973	Chr11:70350812-70350827 (-)	-10 bp
Tssr108972	Chr11:70350783-70350810 (-)	13 bp
Tssr108971	Chr11:70350751-70350775 (-)	47 bp
Tssr108970	Chr11:70350705-70350745 (-)	85 bp
Tssr108969	Chr11:70350684-70350695 (-)	120 bp
Tssr108968	Chr11:70350658-70350667 (-)	147 bp
Tssr108967	Chr11:70350627-70350638 (-)	177 bp
Tssr108966	Chr11:70350575-70350593 (-)	226 bp
Tssr108965	Chr11:70350543-70350556 (-)	260 bp
Tssr108964	Chr11:70350482-70350531 (-)	303 bp
Tssr108963	Chr11:70350456-70350478 (-)	343 bp
Tssr108962	Chr11:70350327-70350340 (-)	476 bp
Tssr108961	Chr11:70349638-70349674 (-)	1,154 bp
Tssr108960	Chr11:70349614-70349628 (-)	1,189 bp
Tssr108959	Chr11:70346757-70346823 (-)	4,020 bp
Tssr108958	Chr11:70346156-70346183 (-)	4,640 bp
Tssr108957	Chr11:70346124-70346143 (-)	4,676 bp
Tssr108956	Chr11:70346047-70346092 (-)	4,740 bp
Tssr108955	Chr11:70346020-70346037 (-)	4,781 bp
Tssr108954	Chr11:70345382-70345387 (-)	5,425 bp
Tssr108953	Chr11:70345288-70345299 (-)	5,516 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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