Gpr4 MGI Mouse Gene Detail - MGI:2441992 - G protein-coupled receptor 4

Symbol

Gpr4
Name

G protein-coupled receptor 4

Feature Type

protein coding gene
IDs

MGI:2441992
NCBI Gene: 319197
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:18946463-18958099 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.46 cM
Mapping Data

1 experiment

SNPs within 2kb

330 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441992	protein coding gene	Chr7:18946463-18958101 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031765	protein coding gene	Chr7:17179469-17191085 (+)
A/J	MGP_AJ_G0031741	protein coding gene	Chr7:16855261-16866825 (+)
AKR/J	MGP_AKRJ_G0031667	protein coding gene	Chr7:17312626-17324590 (+)
BALB/cJ	MGP_BALBcJ_G0031746	protein coding gene	Chr7:17056294-17067935 (+)
C3H/HeJ	MGP_C3HHeJ_G0031468	protein coding gene	Chr7:17580430-17592496 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032212	protein coding gene	Chr7:18061245-18073002 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029278	protein coding gene	Chr7:18501110-18513011 (+)
CAST/EiJ	MGP_CASTEiJ_G0030811	protein coding gene	Chr7:13984296-13995968 (+)
CBA/J	MGP_CBAJ_G0031430	protein coding gene	Chr7:18728740-18743141 (+)
DBA/2J	MGP_DBA2J_G0031585	protein coding gene	Chr7:16791708-16803871 (+)
FVB/NJ	MGP_FVBNJ_G0031537	protein coding gene	Chr7:16655271-16666729 (+)
LP/J	MGP_LPJ_G0031668	protein coding gene	Chr7:17518501-17530529 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031573	protein coding gene	Chr7:18575787-18588361 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032240	protein coding gene	Chr7:16922203-16933702 (+)
PWK/PhJ	MGP_PWKPhJ_G0030535	protein coding gene	Chr7:13880035-13893012 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030362	protein coding gene	Chr7:11631254-11644390 (+)
WSB/EiJ	MGP_WSBEiJ_G0030911	protein coding gene	Chr7:17135279-17146924 (+)

Human Ortholog

GPR4, G protein-coupled receptor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR4, G protein-coupled receptor 4
Synonyms

GPR6C.l
Links

HGNC:4497

NCBI Gene ID: 2828

neXtProt AC: NX_P46093

UniProt: P46093
Chr Location

19q13.32; chr19:45589764-45602212 (-) GRCh38

MGI Vertebrate Homology

Gpr4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR4
Gene Tree

Gpr4

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Phenotype Summary

33 phenotypes from 2 alleles in 4 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

5
Gene trapped

9
Targeted

6
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele display partial neonatal and postnatal lethality, hemorrhages, impaired association of vascular smooth muscle cells with capillaries and small arteries and veins, and impaired contact between mesangial cells and renal glomerular capillaries.

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All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

3
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr4

ZFIN gpr4

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS20893.1

Ensembl

ENSMUSG00000044317 (Evidence)
NCBI Gene

319197

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044317	Ensembl Gene Model \| MGI Sequence Detail	11637	C57BL/6J	± kb
transcript	ENSMUST00000060225	Ensembl \| MGI Sequence Detail	2882	Not Applicable
polypeptide	ENSMUSP00000061243	Ensembl \| MGI Sequence Detail	365	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001644 G-protein coupled receptor 4

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR002276 G protein-coupled receptor 4 orphan

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q8BUD0 2 sites

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 23
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:354640 Gonye EC, et al., Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO(2)-Stimulated Breathing. J Neurosci. 2024 Sep 4;44(36)

TSS for Gpr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64802	Chr7:18946446-18946471 (+)	-4 bp
Tssr64803	Chr7:18946478-18946530 (+)	41 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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